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Endoscopy 2001; 33(11): 985-987
DOI: 10.1055/s-2001-17922
Case Report

© Georg Thieme Verlag Stuttgart · New York

Successful Treatment with Steroids of Upper Gastrointestinal Acute Graft vs. Host Disease After Hematopoietic Stem Cell Transplantation

T. Nishi 1 , K. Okazaki 1 , S. Fujii 1 , K. Uchida 1 , S. Uose 1 , H. Nakase 1 , M. Ohana 1 , T. Nishihara 2 , T. Chiba 1
  • 1 Dept. of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan
  • 2 Dept. of Hematology and Oncology, Kyoto University Hospital, Kyoto, Japan
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Publication History

Publication Date:
18 October 2001 (online)

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A 39-year-old man with acute myeloid leukemia underwent completely matched related hematopoietic stem cell transplantation. On post-transplantation day 83 he was diagnosed as having upper gastrointestinal graft-versus-host disease (GVHD) by endoscopic examination and pathological examination of endoscopic biopsy specimens, and daily administration of 60 mg of water-soluble prednisolone and 50 mg of cyclosporine was started. After steroid therapy, the symptoms of upper gastrointestinal GVHD disappeared completely and endoscopic findings dramatically improved.

References

  • 1 Spencer G D, Shulman H M, Myerson D, et al. Diffuse intestinal ulceration after marrow transplantation: a clinicopathologic study of 13 patients.  Hum Pathol. 1986;  17 621-633
    PubMedGoogle Scholar
  • 2 Weisdorf D J, Snover D C, Haake R, et al. Acute upper gastrointestinal graft-versus-host disease: clinical significance and response to immunosuppressive therapy.  Blood. 1990;  76 624-629
    PubMedGoogle Scholar
  • 3 Spencer G D, Hackman R C, McDonald G B, et al. A prospective study of unexplained nausea and vomiting after marrow transplantation.  Transplantation. 1986;  42 602-607
    PubMedGoogle Scholar
  • 4 Snover D C. Graft-versus-host disease of the gastrointestinal tract.  Am J Surg Pathol. 1990;  14 (Suppl. 1) 101-108
    PubMedGoogle Scholar
  • 5 Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on Acute GVHD Grading.  Bone Marrow Transplant. 1995;  15 825-828
    PubMedGoogle Scholar
  • 6 Robert J P, Robert C H, George B M, et al. Endoscopic and histologic diagnosis of intestinal graft-versus-host disease after marrow transplantation.  Gastrointest Endosc. 1999;  5 612-621
    PubMedGoogle Scholar
  • 7 Washington K, Bentley R C, Green A, et al. Gastric graft-versus-host disease: a blinded histologic study.  Am J Surg Pathol. 1997;  21 1037-1046
    CrossrefPubMedGoogle Scholar
  • 8 Cox G J, Matsui S M, Lo R S, et al. Etiology and outcome of diarrhea after marrow transplantation: a prospective study.  Gastroenterology. 1994;  107 1398-1407
    PubMedGoogle Scholar
  • 9 Roy J, Snover D, Weisdorf S, et al. Simultaneous upper and lower endoscopic biopsy in the diagnosis of intestinal graft-versus-host disease.  Transplantation. 1991;  51 642-646
    PubMedGoogle Scholar
  • 10 Wu D, Hockenberry D M, Brentnall T A, et al. Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients.  Transplantation. 1998;  66 1319-1324
    PubMedGoogle Scholar
  • 11 Wakui M, Okamoto S, Ishida A, et al. Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation.  Bone Marrow Transplant. 1999;  23 573-578
    CrossrefPubMedGoogle Scholar

K. Okazaki,M.D. 

Dept. of Gastroenterology and Endoscopic Medicine
Kyoto University Hospital

Shogoin-Kawara-cho
Sakyo-ku
Kyoto city
Kyoto 606-8507
Japan


Fax: + 81-75-7514303

Email: okak@kuhp.kyoto-u.ac.jp