The development of new antithrombotic drugs to inhibit the blood coagulation system
and to block receptors of platelets represents an important area of medical research.
The results of the efficacy in animal models are of critical importance for the further
development of these compounds for human use. The transferability of such data from
animal to human species still remains controversial. The antithrombotic effects of
direct thrombin inhibitors and a glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonist
were investigated in an experimental thrombosis model using human blood in order to
analyze the feasibility of such a model.
Thrombosis model - GPIIb/IIIa antagonist - thrombin inhibitors - blood coagulation
- platelets