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Synthesis 2001(14): 2119-2123
DOI: 10.1055/s-2001-18053
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© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Synthesis of Novel 5-Substituted-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidines

Mailavaram Raghu Prasada, Akkinepalli Raghu Ram Rao*a, Pamulaparthi Shanthan Raob, Kombu Subramanian Rajana
a Medicinal Chemistry Division, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, 506 009 India
b Organic Division-II, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, A.P., India
Fax: +91(8712)438844, 438800; e-Mail: raghumed@hotmail.com;
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Publication History

Received 20 March 2001
Publication Date:
10 August 2004 (online)

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Abstract

A novel, facile microwave-assisted route for the synthesis of imidazo[1,2-c]thieno[3,2-e]pyrimidines 4 in quantitative yields is reported. The intermediates 4-chlorothieno[2,3-d]pyrimidines 3 were synthesized under one-pot reaction conditions.

Key words

imidazo[1,2-c]thieno[3,2-e]pyrimidines - microwave irradiation - one-pot synthesis - 2-substituted-4-chloro thienopyrimidines