Synthesis 2001(14): 2091-2094
DOI: 10.1055/s-2001-18062
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Simple and Practical Method for Large-Scale Acetylation of Alcohols and Diols Using Bismuth Triflate

Marc D. Carrigan, Derek A. Freiberg, Russell C. Smith, Herbert M. Zerth, Ram S. Mohan*
Department of Chemistry, Illinois Wesleyan University, Bloomington, IL 61701, USA
Fax: 1(309)5563864; e-Mail: rmohan@titan.iwu.edu;
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Publikationsverlauf

Received 7 June 2001
Publikationsdatum:
09. August 2004 (online)

Abstract

A practical method for large-scale acetylation of 1° and 2° alcohols as well as diols has been developed. The acetylation proceeds smoothly in MeCN with as little as 0.1 mol% bismuth triflate in good yields.

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The authors wish to thank an anonymous referee for useful suggestions regarding a possible mechanism.