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Synlett 2001; 2001(11): 1777-1778
DOI: 10.1055/s-2001-18078
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Simple, Facile and Highly Selective Tetrahydropyranylation of Alcohols Using Silica Chloride

N. Ravindranath* , C. Ramesh, Biswanath Das
  • *Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India; Fax + 91(40)7 17 33 87, + 91(40)7 17 37 57; E-mail: biswanathdas@yahoo.com
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Publication Date:
29 October 2001 (online)

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A simple and efficient process for tetrahydropyranylation of alcohols has been developed by reacting with dihydropyran at room temperature in presence of catalytic amount of silica chloride. The process is highly selective for monoprotection of the hydroxyl groups of symmetric diols.

alcohols - tetrahydropyranylation - silica chloride - symmetric diols - monoprotection