Planta Med 2001; 67(8): 745-747
DOI: 10.1055/s-2001-18339
Letter

© Georg Thieme Verlag Stuttgart · New York

In Vitro Anti-Inflammatory Effects of Quercetin 3-O-Methyl Ether and Other Constituents from Rhamnus Species

Bai-Luh Wei1 , Chai-Ming Lu2 , Lo-Ti Tsao3 , Jih-Pyang Wang3 , Chun-Nan Lin4,*
  • 1 National University of Kaohsiung, Kaohsiung, Taiwan, Republic of China
  • 2 Ta-Jen Institute of Technology, Ping Tung Hsieng, Taiwan, Republic of China
  • 3 Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
  • 4 School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
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Publikationsverlauf

November 9, 2000

December 17, 2000

Publikationsdatum:
09. November 2001 (online)

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Abstract

The anti-inflammatory activities of the isolated flavonoids, quercetin 3-O-methyl ether (1), kaempferol (2), and quercetin (3), of Rhamnus nakaharai, and anthraquinone, frangulin B (4), of Rhamnus formosana, were assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells, neutrophils, macrophages, and microglial cells. Compounds 1 - 3 strongly inhibited the release of β-glucuronidase and lysozyme from rat neutrophils stimulated with formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB). Compound 1 strongly inhibited superoxide anion formation in fMLP/CB or phorbol 12-myristate 13-acetate (PMA)-stimulated rat neutrophils. Compound 1 exhibited potent inhibitory effect on tumor-necrosis factor-α ( TNF-α) formation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells while 1 and 4 showed potent inhibitory effects on TNF-α formation in LPS/IFN-γ (interferon-γ)-stimulated murine microglial cell lines N9.

References

Dr. Chun-Nan Lin

School of Pharmacy

Kaohsiung Medical University

Kaohsiung

Taiwan 807

Republic of China

eMail: lincna@cc.kmu.edu.tw

Fax: +886-7-5562365