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Planta Med 2001; 67(8): 757-760
DOI: 10.1055/s-2001-18348
Letter

© Georg Thieme Verlag Stuttgart · New York

Hypotensive Effect of Chemical Constituents from Aloe barbadensis

Rubeena Saleem1,*, Shaheen Faizi2 , Bina Shaheen Siddiqui2 , Muhammad Ahmed1 , Syed Ahmed Hussain1 , Aamer Qazi1 , Ahsana Dar2 , Syed Iqbal Ahmad1 , Mahmood Hussain Qazi1 , Shamim Akhtar3 , Syed Nazrul Hasnain3
  • 1 Dr. H.M.I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan
  • 2 H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan
  • 3 Department of Biochemistry, University of Karachi, Pakistan
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Publication History

December 8, 2000

January 28, 2001

Publication Date:
09 November 2001 (online)

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Abstract

Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).

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Dr. Rubeena Saleem

Dr. H.M.I. Institute of Pharmacology and Herbal Sciences

Hamdard University

Karachi-74600

Pakistan

Email: rs127pk@yahoo.com

Fax: +92-21 699-6002, 664-11755