Planta Med 2001; 67(8): 743-744
DOI: 10.1055/s-2001-18355
Letter

© Georg Thieme Verlag Stuttgart · New York

Phenolic Compounds with Anti-Inflammatory Activity from Eupatorium buniifolium

Liliana Muschietti1,*, Susana Gorzalczany2 , Graciela Ferraro1 , Cristina Acevedo2 , Virginia Martino1
  • 1 Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
  • 2 Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
Further Information

Publication History

October 27, 2000

February 24, 2001

Publication Date:
09 November 2001 (online)

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Abstract

Anti-inflammatory activity was detected in the CH2Cl2 extract of the aerial parts of Eupatorium buniifolium using the TPA-mouse ear model. Three compounds isolated from this extract, by bioassay-guided fractionation, significantly inhibited the inflammatory response. The compounds were identified as 5,7,5′-trihydroxy-3,6,2′,4′-tetramethoxyflavone (1), scopoletin (2) and centaureidin (3) which inhibited the edema by 67.3 %, 59.8 % and 49.7 %, respectively, at a dose of 1 mg/ear.