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Planta Med 2001; 67(8): 722-725
DOI: 10.1055/s-2001-18357
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Evaluation of In Vitro Activity of Aurones and Related Compounds against Cryptosporidium parvum

Oliver Kayser1,*, W. Ray Waters2 , Keith M. Woods3 , Steve J. Upton3 , Janet S. Keithly4 , Albrecht F. Kiderlen5
  • 1 Freie Universität Berlin, Institut für Pharmazie, Pharmazeutische Biotechnologie, Berlin, Germany
  • 2 National Animal Disease Center, Bacterial Diseases of Livestock Research Unit, Ames, Iowa, USA
  • 3 Kansas State University, Biology Department, Manhattan, Kansas, USA
  • 4 Wadsworth Center, David Axelrod Institute for Public Health, Albany, New York, USA
  • 5 Robert Koch-Institut, Berlin, Germany
Further Information

Publication History

October 27, 2000

March 6, 2001

Publication Date:
09 November 2001 (online)

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Abstract

The efficacy of a series of aurones, auronols and 4-methoxy-α-pyrones has been screened for the ability to inhibit the intracellular growth of the parasitic protist Cryptosporidium parvum using an in vitro enzyme linked immunosorbent assay (ELISA). All aurones of this series were active at 25 to 100 μM. 10 of 19 aurones inhibited the intracellular growth of C. parvum by > 90 % with moderate to no toxicity. The most active of these was 3′,4′,6-trihydroxy-2-[phenylmethylene]-3(2H)-benzofuranone.

Key words

Aurones - Cryptosporidium - ELISA assay - protist chemotherapy - drug testing

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Dr. Oliver Kayser

Freie Universität Berlin

Institut für Pharmazie

Pharmazeutische Biotechnologie

Kelchstraße 31

12169 Berlin

Germany

Email: kayser@zedat.fu-berlin.de

Fax: +49-30-838 50605

Phone: Tel.: +49-30-838 50689