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Z Gastroenterol 2001; 39(11): 937-956
DOI: 10.1055/s-2001-18536
Leitlinien
© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Leitlinien der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten zur Behandlung der Dyspepsie

Guidelines of the German Society of Metabolic and Digestive Diseases for the therapy of dyspesiaP. Malfertheiner, G. Holtmann, U. Peitz, B. Birkner, R. Arnold, J. Hotz, A. Leodolter, J. Mössner, B.-P Robra
  • 1für die Teilnehmer der Leitlinien-Konferenz der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten
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Publication History

Publication Date:
21 November 2001 (online)

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Vorbemerkungen

Auf den Oberbauch bezogene Symptome sind in unserer Bevölkerung sehr verbreitet und häufig Anlass für ärztliche Konsultationen. Mit dem Ziel, die Grundlagen für eine rational begründete Diagnostik und Therapie dieses Krankheitskomplexes zu erarbeiten, sind in den letzten Jahren verschiedene internationale Expertengremien aktiv geworden [1 4].

Im Mai 1999 fand in Magdeburg eine Leitlinen-Konferenz der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten statt, die rational begründete Empfehlungen für die Diagnostik und Therapie bei Dyspepsie entwickeln sollte. Neben Gastroenterologen waren in die Konferenz auch Allgemeinmediziner, Pädiater sowie Psychosomatiker und Vertreter der Kostenträger eingebunden.

In der Vorbereitungsphase der Leitlinienkonferenz wurden folgende 3 Themenkomplexe festgelegt und die eingeladenen Teilnehmer entsprechend den 3 Arbeitsgruppen zugeordnet:

Grundlagen der Dyspepsie: Definition, Epidemiologie, Pathophysiologie, diagnostische Verfahren klinisches Vorgehen bei Dyspepsie (klinische Anwendung der Diagnostik, Therapie) klinische Evaluierung und Gesundheitsökonomie

Mittels Fragebogen wurden Bewertungen und Kommentare zu vorbereiteten Aussagen von den Mitgliedern der 3 Arbeitsgruppen eingeholt und allen Teilnehmern der Leitlinienkonferenz zur Verfügung gestellt.

Die Bewertung der Aussagen und Empfehlungen erfolgte nach dem Evidenzgrad (s. Tab. [1]) basierend auf den Richtlinien von S. H. Woolf [5].

In der Leitlinienkonferenz selbst wurden zunächst in den 3 Arbeitsgruppen die Aussagen und Empfehlungen ausgearbeitet, durch Literatur belegt und erneut nach dem Evidenzgrad bewertet. In einer abschließenden Konferenz stimmten alle Teilnehmer über die Aussagen und Empfehlungen ab, gegebenfalls wurden Kommentare ergänzt.

Tab. 1 Stärke der Evidenz I-1 Evidenz durch Metaanalysen randomisierter kontrollierter Studien I-2 Evidenz durch mindestens eine geeignet geplante randomisierte kontrollierte Studie II-1 Evidenz durch gut geplante kontrollierte Studien ohne Randomisierung II-2 Evidenz durch gut geplante Kohorten- oder Fallkontrollstudien, vorzugsweise von mehr als einem Studienzentrum oder einer Forschergruppe II-3 Evidenz durch Vergleiche von Zeitabschnitten oder Zentren mit oder ohne Intervention, dramatische Veränderungen in Experimenten ohne Kontrollgruppe können auch in diese Kategorie eingestuft werden III Evidenz durch Meinungsbildner, basierend auf klinischen Erfahrungen, Beobachtungsstudien oder Berichten von Expertenkommissionen

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Anschrift für die Verfasser

Prof. Dr. med. Peter Malfertheiner

Otto-von-Guericke Universität Magdeburg
Klinik für Gastroenterologie, Hepatologie und
Infektiologie

Leipziger Straße 44

39120 Magdeburg

Email: peter.malfertheiner@medizin.uni-magdeburg.de