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Exp Clin Endocrinol Diabetes 2001; 109(Suppl 2): S384-S399
DOI: 10.1055/s-2001-18597
Treatment

© Johann Ambrosius Barth

Islet transplantation: Present clinical situation and future aspects

R. G. Bretzel, M. Brendel, M. Eckhard, D. Brandhorst, C. Jaeger, E. Hatziagelaki, K. Federlin
  • Third Medical Department and Policlinic, Justus-Liebig-University, Giessen, Germany
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Publikationsdatum:
23. November 2001 (online)

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Summary:

Beta-cell replacement either by pancreatic organ or islet cell transplantation is the only treatment to achieve an insulin-independent, normoglycemic state and to avoid hypoglycemic episodes in patients with type 1 diabetes mellitus. This article will review the state-of-the-art in clinical islet cell transplantation at the dawn of the new millenium and will provide an outlook on the basis of extended personal experience.

Key words:

Islet transplantation - kidney transplantation - end-stage renal disease - alloimmunity - autoimmunity - immunosuppression - immunotolerance - gene therapy