Planta Med 2001; 67(9): 820-824
DOI: 10.1055/s-2001-18858
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Photosensitization and Mutation Induced in Escherichia coli and Saccharomyces cerevisiae Strains by Dorstenin, a Psoralen Analog Isolated from Dorstenia bahiensis

Daíse Lopes1 , Rodrigo Rodrigues deOliveira2 , Maria Auxiliadora Coelho Kaplan2 , Claudia Santos Lage3 , Alvaro C. Leitão3
  • 1 EMBRAPA- Agroindústria de Alimentos, Rio de Janeiro, Brazil
  • 2 Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • 3 Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Weitere Informationen

Publikationsverlauf

November 30, 2000

April 22, 2001

Publikationsdatum:
06. Dezember 2001 (online)

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Abstract

Dorstenin, 5-[3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-butoxy]-7H-furo[3, 2-g] [1] benzopyran-7-one, is a psoralen analog recently isolated from Dorstenia species (Moraceae). In order to characterize its biological activity, its photosensitizing and mutational properties were measured in wild-type E. coli and S. cerevisiae and also in strains carrying mutations which affect DNA repair. Compared to the high activities of psoralen and bergapten, dorstenin showed lower genotoxic effect.

References

Dr. Alvaro C. Leitão

Instituto de Biofisica Carlos Chagas Filho

Universidade Federal do Rio de Janeiro

CCS-Bloco G

2149-900, Rio de Janeiro

Brazil

eMail: acleitao@biof.ufrj.br

Fax: +55-21-2280-8193