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Semin Thromb Hemost 2001; 27(6): 667-674
DOI: 10.1055/s-2001-18871
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Anticoagulant Factor Concentrates in Disseminated Intravascular Coagulation: Rationale for Use and Clinical Experience

Evert de Jonge1 , Tom van der Poll2 , Jozef Kesecioglu1 , Marcel Levi3
  • 1Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands
  • 2Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
  • 3Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
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Publikationsverlauf

Publikationsdatum:
06. Dezember 2001 (online)

    Lizenzen und Reprints

ABSTRACT

Natural inhibitors of coagulation, in other words, antithrombin (AT), the protein C system, and tissue factor pathway inhibitor (TFPI), play an important role in controlling the activation of coagulation during disseminated intravascular coagulation (DIC). Furthermore, they may not only influence coagulation but also attenuate inflammatory responses during sepsis. Low circulating levels of AT and protein C have been associated with poor outcome. Replacement therapy with AT, activated protein C (APC), and TFPI has been shown to attenuate thrombin generation and to reduce mortality in experimental sepsis models. Experience with AT and APC in patients is promising. Data from large phase III trials of AT and APC as treatment of patients with severe sepsis will soon be available. Recombinant TFPI is currently in phase II clinical trials for severe sepsis.

KEYWORD

Sepsis - antithrombin - protein C - tissue factor pathway inhibitor - TFPI - inflammation

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