Hintergrund und Fragestellung: Akute kardiovaskuläre Krankheitsereignisse können durch körperliche und mentale
Belastungen getriggert werden. Korreliert demnach auch die typische zirkadiane Variation
von Arrhythmierezidiven bei Defibrillatorträgern (morgendliche Ereignishäufung)
mit der individuellen Verteilung gewohnter physischer und mentaler Aktivitäten im
Alltag?
Patienten und Methodik: Bei 29 Patienten mit Arrhythmierezidiven an mindestens 3 Tagen nach Defibrillatorimplantation
wurde die Verteilung gewohnter Aktivitäten mit Hilfe eines neu entwickelten Fragebogens
in einem ärztlichen Interview erfasst, graduiert und mit der individuellen zirkadianen
Ereignisverteilung im Langzeitverlauf korreliert.
Ergebnisse: Das höchste Niveau physischer bzw. mentaler Aktivitäten fand sich bei 55 % bzw.
23 % der Patienten zur Tageszeit mit den meisten Rezidiven. Ein Vergleich des Aktivitätsniveaus
in der Tagesperiode mit den häufigsten Ereignissen und dem mittleren Aktivitätsniveau
in den übrigen Tagesperioden (ohne Schlafzeit) ergab signifikant höhere Werte für
die physische Aktivität in dem Tageszeitraum mit individuellem Ereignisgipfel. Es
bestand eine positive Korrelation zwischen der tageszeitlichen Variation der Arrhythmieinzidenz
und der Summe aller Aktivitäten (r = 0,34, p < 0,05) sowie der physischen Aktivitäten
allein (r = 0,25, p = 0,056), wohingegen ein Zusammenhang mit nur der mentalen Aktivitätsverteilung
nicht aufgezeigt werden konnte (r = 0,02, p = 0,84).
Schlussfolgerung: Die tageszeitliche Variation von kardiovaskulären Krankheitsereignissen kann als
maßgeblicher Einflussfaktor auf die habituelle tageszeitliche Verteilung von Alltagsaktivitäten
diskutiert werden.
Daily activities and circadian variation of ventricular tachyarrhythmias in patients with implanted defibrillator
Background and study aim: Acute cardiovascular events may be triggered by physical and mental stress. Does
also the typical circadian variation of arrhythmia recurrence (morning peak of events)
in patients with implanted cardioverter-defibrillator correlate with the individual
circadian variation of physical and mental daily activities?
Patients and methods: In 29 consecutive patients with a minimum of three documented ventricular tachyarrhythmias
after defibrillator implantation the circadian variation of habitual daily activities
was determined in a standardized interview and compared to the individual circadian
variation of arrhythmic events saved in the defibrillator event memory during long-term
follow-up.
Results: The habitually highest physical and mental activity was determined during the time
period with most arrhythmic events in 55 % and 23 % of patients, respectively. A
comparison of the level of activity during the time period with the highest event
frequency to the mean activity level during the rest of the day (without sleeping
time) revealed significantly higher physical activity during the time of day with
the highest arrhythmia recurrence. There was a positive correlation between circadian
variation of arrhythmic events and the sum of all activities (r = 0.34, p < 0.05)
and physical activities alone (r = 0.25, p = 0.056) while a relationship to mental
activities alone could not be shown (r = 0.02, p = 0.84)
Conclusion: The circadian variation of acute cardiovascular events may be discussed as an essential
factor influencing the circadian variation of habitual daily activities in patients
with cardiac disease.
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Korrespondenz
Priv.-Doz. Dr. Roland Fries
Innere Medizin III, Kardiologie/Angiologie, Universitätskliniken des Saarlandes
66421 Homburg/Saar
Phone: 06841/1623016
Fax: 06841/1623369
Email: fries@med-in.uni-sb.de