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Deutsche Zeitschrift für Onkologie 2001; 33(3): 91-99
DOI: 10.1055/s-2001-19447
Wissenschaft & Forschung

Karl F. Haug Verlag, in: MVH Medizinverlage Heidelberg GmbH & Co. KG

Electro-hyperthermia: a New Paradigm in Cancer Therapy

Andras Szasz1,2 , Oliver Szasz1 , Nora Szasz3
  • 1 Group Biotech. Faculty Engineering, Szent Istvan University, Gödöllö, Hungary
  • 2 Faculty of Engineering, Strathclyde University, Glasgow, Great-Britain
  • 3 Div. Bioengineering and Environ. Health, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA
Further Information

Publication History

Publication Date:
08 January 2002 (online)

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Summary

Hyperthermia is a rapidly developing treatment method in tumor-therapy. The classical effect is based on well-focused energy absorption targeting the malignant tissue. The treatment temperature has been considered as the main technical parameter. Unfortunately, the heat-shock protein (HSP) synthesis may considerably suppress the treatment's efficiency, adapting cells to survive the shock. Electro-hyperthermia heats up the targeted tissue by means of electricity, producing less HSP-synthesis in the cells than a usual hyperthermia process. The main idea is to keep the energy absorption in the extracellular liquid and, by heating it, increase the ion-mobility, intensify the metabolic rate of the cells, and destroy the cell membrane before the heat-shock activates the intra-cellular HSP mechanisms.

Zusammenfassung

Hyperthermie ist eine sich schnell entwickelnde Behandlungsmethode in der Tumortherapie. Der klassische Effekt basiert auf einer genau gebündelten Energieabsorption, die auf das bösartige Gewebe zielt. Die Behandlungstemperatur wurde als der wichtigste technische Parameter angesehen. Leider kann die Hitzeschockprotein-Synthese (HSP) die Wirksamkeit der Behandlung erheblich beeinträchtigen, weil sich die Zellen entsprechend anpassen, um den Schock zu überstehen. Bei der Elektro-Hyperthermie wird das Zielgewebe mittels Elektrizität erwärmt, wodurch es in den Zellen zu einer geringeren Hitzeschockprotein-Synthese (HSP) als beim herkömmlichen Hyperthermie-Prozess kommt. Die Hauptidee besteht darin, die Energieabsorption auf die Extrazellularflüssigkeit zu beschränken und durch Erhitzen die Ionenmobilität zu erhöhen, die Stoffwechselrate der Zellen zu intensivieren und die Zellmembran zu zerstören, bevor durch den Hitzeschock der intrazellulare Mechanismus der Hitzeschockprotein-Synthese aktiviert wird.

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Correspondence to:

Prof. Dr. A. Szasz

Szent Istvan krt.20

Budapest, H-1137

Hungary

Email: profszasz@oncotherm.org