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Zentralbl Gynakol 2001; 123(11): 609-618
DOI: 10.1055/s-2001-19514
Übersicht

© Georg Thieme Verlag Stuttgart · New York

Die Rolle der Zytokine an der fetomaternalen Grenze

The role of cytokines at the fetomaternal interfaceK. Geis, J. Dietl
  • Frauenklinik der Bayerischen Julius-Maximilians-Universität Würzburg
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Publikationsverlauf

Publikationsdatum:
14. Januar 2002 (online)

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Zusammenfassung

Für das Überleben des semiallogenen Embryos im maternalen Organismus sind verschiedene Mechanismen notwendig. Neben dem Fehlen der klassischen MHC-Klasse-I- und -II-Antigenen auf dem Trophoblasten, kommt vor allem den Zytokinen an der fetomaternalen Grenzzone eine große Bedeutung zu. Eine Vielzahl an Zytokinen reguliert die immunologischen Prozesse, wobei besonders dem Th1/Th2-Gleichgewicht eine entscheidende Rolle zugesprochen wird. Außerdem besteht an der fetomaternalen Grenzzone im Gegensatz zum peripheren Blut eine veränderte Zusammensetzung an immunkompetenten Zellen. Zahlreiche Wechselwirkungen bestehen auch zwischen dem endokrinen und dem Immunsystem, indem verschiedene Hormone modulierend auf die Sekretion der einzelnen Zytokine wirken. Im Bereich der Reproduktionsmedizin ist die Aufklärung dieser Funktionen von großem Interesse, um zukünftig möglicherweise Störungen vor allem in der Frühschwangerschaft behandeln zu können.

The role of cytokines at the fetomaternal interface

Summary

Various mechanisms are necessary for regulating the survival of the semiallogenic embryo in the maternal organism. In addition to the lack of classical MHC class I and II antigens at the trophoblast the cytokines play an important role at the fetomaternal interface. Different cytokines regulate the immunological processes with an emphasis on the Th1/Th2 balance. In contrast to the peripheral blood there is a certain composition of immune competent cells at the fetomaternal interface. There are many different interactions between the endocrine and immunological system. Hormones modulate the secretion of certain cytokines and vice versa. In reproductive medicine it is of specific interest to evaluate these functions for treating problems during the early pregnacy.

Schlüsselwörter

Zytokine - Plazenta - Th1/Th2 - Schwangerschaft - Hormone

Key words

Cytokines - placenta - Th1/Th2 - pregnancy - hormones

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Dr. Karin Geis

Frauenklinik der Julius-Maximilians-Universität Würzburg

Josef-Schneider-Str. 4

D-97080 Würzburg

Telefon: 09 31-2 01-52 51

Fax: 09 31-2 01-34 06

eMail: karin.geis@gmx.de