Z Gastroenterol 2002; 40(1): 33-36
DOI: 10.1055/s-2001-19634
Kasuistiken
© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Signet-ring Cell Carcinoma of unknown primary Location. Metastatic to lower back Musculature - Remission following FU/FA Chemotherapy

Siegelringzellkarzinom mit unbekanntem Primarius und Metastasierung in die untere Rückenmuskulatur - Remission nach FU/FA-ChemotherapieJ. Heidemann1 , H. R. Gockel1 , G. Winde3 , H. Herbst3 , W. Domschke1 , N. Lügering1
  • 1Department of Medicine B, University of Münster
  • 2Department of Surgery, Klinikum Kreis Herford
  • 3Gerhard-Domagk-Institute of Pathology, University of Münster
Further Information

Publication History

19.3.2001

24.7.2001

Publication Date:
21 January 2002 (online)

Abstract

The detection of gastrointestinal signet-ring cell carcinoma by endoscopy can be a diagnostic challenge. The main clinical features include atypical metastasis and a poor prognosis.

We present a case of a metastasizing signet-ring cell carcinoma with unknown primary location arising in 71-year-old female. Following 6 cycles of a routine intravenous FU/FA chemotherapy, an almost complete remission could be observed. After 2 years of follow up, metastatic recurrence was detected to the lower back musculature.

This case report emphasizes the difficulties in diagnosing signet-ring cell carcinoma by endoscopy and demonstrates an unusual clinical course.

Zusammenfassung

Siegelringzellkarzinome des Gastrointestinaltraktes können eine diagnostische Herausforderung an den Endoskopiker darstellen. Sie sind oftmals durch atypische Metastasierung und eine schlechte Prognose gekennzeichnet.

In diesem Fallbericht wird ein bei einer 71-jährigen Patientin aufgetretenes Siegelringzellkarzinom mit unklarem Primarius vorgestellt. Nach 6 Zyklen einer FU/FA-Chemotherapie war eine nahezu vollständige Remission des Tumors zu beobachten. Nach 2 Jahren Verlaufsbeobachtung ließ sich eine große Metastase des Siegelringzellkarzinoms im Bereich der Muskulatur des unteren Rückens nachweisen.

Dieser Fallbericht verdeutlicht die mitunter schwierige endoskopische Diagnostik von Siegelringzellkarzinomen und beschreibt einen außergewöhnlichen klinischen Verlauf.

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Dr. med. Jan Heidemann

Department of Medicine B
University of Münster

Albert-Schweitzer-Straße 33

48129 Münster

Email: Jan_Heidemann@hotmail.com