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Synlett 2001; 2001(1): 0069-0072
DOI: 10.1055/s-2001-9715
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Enantioselective Aldol Reaction of Trimethoxysilyl Enol Ethers with Aldehydes Catalyzed by p-Tol-BINAP · AgF Complex

Akira Yanagisawa* , Yoshinari Nakatsuka, Kenichi Asakawa, Hiromi Kageyama, Hisashi Yamamoto
  • *Graduate School of Engineering, Nagoya University, CREST, Japan Science and Technology Corporation (JST) Chikusa, Nagoya 464-8603, Japan; Fax +81-52-789-3222; E-mail: yamamoto@cc.nagoya-u.ac.jp
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Publication Date:
31 December 2001 (online)

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New catalytic asymmetric Mukaiyama-type aldol reaction using trimethoxysilyl enol ethers was achieved using p-Tol-BINAP · AgF complex as a catalyst. High syn- and enantioselectivities were obtained both from the E- and Z-silyl enol ethers.

enantioselective aldol reaction - silyl enol ethers - aldehydes - BINAP · silver(I) complex - asymmetric catalysis