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Synthesis 2001; 2001(1): 0055-0062
DOI: 10.1055/s-2001-9761
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Microwave Assisted Synthesis of 1-Aryl-3-dimethylaminoprop-2-enones: A Simple and Rapid Access to 3(5)-Arylpyrazoles

Anna-Katharina Pleier* , Holger Glas, Manja Grosche, Peter Sirsch, Werner R. Thiel
  • *Institut für Chemie, Technische Universität Chemnitz, Straße der Nationen 62, 09111 Chemnitz, Germany; Fax +49(371)5 31 18 33; E-mail: werner.thiel@chemie.tu-chemnitz.de
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Publication Date:
31 December 2001 (online)

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Condensation of aromatic acyl compounds with N,N-dimethylformamide diethyl acetal in a pressure tube under microwave heating gives 1-aryl-3-dimethylaminoprop-2-enones in almost quantitative yields. In the presence of hydrazine, these intermediates are transferred to the corresponding 3-arylpyrazoles.

Claisen condensation - aminopropenones - pyrazoles - chromone - microwaves - cyclizations