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Synthesis 2002(1): 0034-0038
DOI: 10.1055/s-2002-19290
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Simple Route to N-ω-Chloroalkylisatins from Cyclic t-Anilines, Oxalyl Chloride and DABCO

Ying Cheng*a, Yu-Hua Zhana, Otto Meth-Cohn*b
a Chemistry Department, Beijing Normal University, Beijing 100875, China
e-Mail: yincheng@public2east.net.cn;
b Chemistry Department, University of Sunderland, Sunderland SR1 3SD, U.K.
e-Mail: otto.meth-cohn@sunderland.ac.uk;
Further Information

Publication History

Received 7 September 2001
Publication Date:
04 August 2004 (online)

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Abstract

para-Substituted N-phenylpyrrolidines, -piperidines, -perhydroazepines and -morpholines react with oxalyl chloride and DABCO to give the pharmaceutically useful intermediates, N-ω-haloalkylisatins, under mild conditions and generally good yields.

Key words

cyclic t-anilines - oxalyl chloride - DABCO - N-ω-haloalkylisatins

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