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Synthesis 2002(1): 0075-0078
DOI: 10.1055/s-2002-19308
DOI: 10.1055/s-2002-19308
PAPER
© Georg Thieme Verlag Stuttgart · New York
Microwave Assisted Synthesis of 1,5-Disubstituted Hydantoins and Thiohydantoins in Solvent-Free Conditions
Weitere Informationen
Received
28 June 2001
Publikationsdatum:
04. August 2004 (online)
Publikationsverlauf
Publikationsdatum:
04. August 2004 (online)
Abstract
1,5-Disubstituted hydantoins/thiohydantoins 3a-p have been synthesized in 81-95% yield by a microwave-promoted solvent-free condensation of arylglyoxals 1 and phenylurea/thiourea 2 using PPE as a reaction mediator. This method can be extended towards the parallel synthesis of 3. The workup is simple and involves treatment with ice-cold water.
Key words
arylglyoxals - solvent-free conditions - polyphosphoric ester (PPE) - microwave activation - hydantoins
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