Inflammatory Bowel Disease

This article reviews a selection of 50 papers on inflammatory bowel disease published between April 2000 and June 2001. The new information summarized here includes: the discovery of the association of the NOD2 gene with Crohn's disease; the role of bacteria and the modulating effects of probiotics; the inverse association of appendectomy and ulcerative colitis; progress in imaging based on magnetic resonance imaging and leukocyte scintigraphy; assessment of the value of anti-Saccharomyces cerevisiae antibodies in the screening of inflammatory bowel disease and differentiation between ulcerative colitis and Crohn's disease; and risk factors and management of dysplasia and cancer. This article does not review all therapeutic aspects, but focuses on smoking cessation; anti-tumor necrosis factor antibody treatments; the usefulness of measuring erythrocyte 6-thioguanine metabolite levels to optimize purine analogue therapy; strictureplasty; and the long-term results of ileoanal anastomosis.

References

• 1 Hugot J P, Chamaillard M, Zouali H. et al . Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.  Nature. 2001;  411 599-603
• 2 Ogura Y, Bonen D K, Inohara N. et al . A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.  Nature. 2001;  411 603-606
• 3 Hampe J, Cuthbert A, Croucher P J. et al . Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.  Lancet. 2001;  357 1925-1928
• 4 Laharie D, Debeugny S, Peeters M. et al . Inflammatory bowel disease in spouses and their offspring.  Gastroenterology. 2001;  120 816-819
• 5 Pardi D S, Tremaine W J, Sandborn W J. et al . Early measles virus infection is associated with the development of inflammatory bowel disease.  Am J Gastroenterol. 2000;  95 1480-1485
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• 7 Sutton C L, Kim J, Yamane A. et al . Identification of a novel bacterial sequence associated with Crohn's disease.  Gastroenterology. 2000;  119 23-31
• 8 Masseret E, Boudeau J, Colombel J F. et al . Genetically related Escherichia coli strains associated with Crohn's disease.  Gut. 2001;  48 320-325
• 9 Andersson R E, Olaison G, Tysk C, Ekbom A. Appendectomy and protection against ulcerative colitis.  N Engl J Med. 2001;  344 808-814
• 10 Jarnerot G, Andersson M, Franzen L. Laparoscopic appendectomy in patients with refractory ulcerative colitis.  Gastroenterology. 2001;  120 1562-1563
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• 20 Bezabeh T, Somorjai R L, Smith I C. et al . The use of ¹H magnetic resonance spectroscopy in inflammatory bowel diseases: distinguishing ulcerative colitis from Crohn's disease.  Am J Gastroenterol. 2001;  96 442-448
• 21 Maunoury V, Mordon S, Geboes K. et al . Early vascular changes in Crohn's disease: an endoscopic fluorescence study.  Endoscopy. 2000;  32 700-705
• 22 Matsuhashi N, Nakajima A, Suzuki A. et al . Long-term outcome of non-surgical strictureplasty using metallic stents for intestinal strictures in Crohn's disease.  Gastrointest Endosc. 2000;  51 343-345
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• 25 Rajan E, Herman L J, Sorbi D. et al . Topical formalin therapy by means of an endoscopic applicator for control of ileoanal pouch ulcer bleeding.  Gastrointest Endosc. 2000;  52 422-424
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• 36 Cosnes J, Beaugerie L, Carbonnel F, Gendre J P. Smoking cessation and the course of Crohn's disease: an intervention study.  Gastroenterology. 2001;  120 1093-1099
• 37 Hilsden R J, Hodgins D, Czechowsky D. et al . Attitudes toward smoking and smoking behaviors of patients with Crohn's disease.  Am J Gastroenterol. 2001;  96 1849-1853
• 38 Ricart E, Panaccione R, Loftus E V. et al . Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: the first 100 patients.  Am J Gastroenterol. 2001;  96 722-729
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• 41 Colombel J F, Ferrari N, Debuysere H. et al . Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.  Gastroenterology. 2000;  118 1025-1030
• 42 Rajapakse R O, Korelitz B I, Zlatanic J. et al . Outcome of pregnancies when fathers are treated with 6-mercaptopurine for inflammatory bowel disease.  Am J Gastroenterol. 2000;  95 684-688
• 43 Gionchetti P, Rizzello F, Venturi A. et al . Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial.  Gastroenterology. 2000;  119 305-309
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• 47 Milsom J, Hammerhofer K, Bohm B. et al . Prospective, randomized trial comparing laparoscopic vs. conventional surgery for refractory ileocolic Crohn's disease.  Dis Colon Rectum. 2001;  44 1-9
• 48 Young-Fadok T M, Hall-Long K, McConnell E J. et al . Advantages of laparoscopic resection for ileocolic Crohn's disease.  Surg Endosc. 2001;  15 450-454
• 49 Tichansky D, Cagir B, Yoo E. et al . Strictureplasty for Crohn's disease: meta-analysis.  Dis Colon Rectum. 2000;  43 911-919
• 50 Regimbeau J M, Panis Y, Pocard M. et al . Long-term results of ileal pouch-anal anastomosis for colorectal Crohn's disease.  Dis Colon Rectum. 2001;  44 769-778
• 51 Yu C S, Pemberton J H, Larson D. Ileal pouch-anal anastomosis in patients with indeterminate colitis: long-term results.  Dis Colon Rectum. 2000;  43 1487-1496