Synthesis of Benzo[c]Phenanthridine Alkaloids, Using a Novel Palladium-Phosphine Combination System - Pd(OAc)₂, DPPP, and Bu₃P

Abstract

Total synthesis of several benzo[c]phenanthridine alkaloids was accomplished via an aryl-aryl coupling reaction using a novel Pd reagent prepared from Pd(OAc)₂, DPPP, and Bu₃P. This is a versatile method for the coupling reactions of not only aryl triflates and arenes but also aryl halides and arenes.

Key words

intramolecular aryl-aryl coupling - ring closure - palladium reagent - halo-amide - triflate-amide

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