Abstract
The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-β-D-glucopyranoside (1) and (-)-terredionol (2). Compound 1 displays radical scavenging and lipid peroxidation inhibitory activity comparable to those of Trolox™C, ascorbic acid or quercetin.
References
-
1 Khachatourians G G. Biochemistry and molecular biology of entomopathogenic fungi. In: Howard DE, Miller JD, editors The Mycota VI, Human and Animal Relationships. Berlin; Springer 1996: 331-63
-
2
Evtushenko E V.
Regioselective methylation of methyl glycopyranosides with diazomethane in the presence of transition-metal chlorides and of boric acid.
Carbohydr. Res..
1999;
316
187-200
-
3
Sekiguchi J, Katayama S, Yamada Y.
6-Methyl-1,2,4-benzenetriol, a new intermediate in penicillic acid biosynthesis in Penicillium cyclopium
.
Appl. Environm. Microbiol..
1987;
53
1531-5
-
4
Tsuda Y, Nunozawa T, Nitta K, Yamamoto Y.
Stereochemical correlation of di- and trihydroxy-β-diketone fungal metabolites, (-)-terredionol and terremutin hydrate, with sugar alcohols: the absolute configuration of (-)-terredionol.
Chem. Pharm. Bull..
1980;
28
920-5
-
5
Takao T, Kitatani F, Watanabe N, Yagi A, Sakata K.
A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and jellyfish.
Biosci. Biotech. Biochem..
1994;
58
1780-3
-
6
Gamez E JC, Luyengi L, Lee S K, Zhu L F, Zhou B N, Fong H HS,. et al .
Antioxidant flavonoid glycosides from Daphniphyllum calycinum
.
J. Nat. Prod..
1998;
61
706-8
-
7
Cotelle N, Bernier J L, Catteau J B, Pommery J, Wallet J C, Gaydou E M.
Antioxidant properties of hydroxy flavones.
Free Radical Biology and Medicine.
1996;
20
35-43
Prof. Dr. Matthias Hamburger
Institute of Pharmacy
Friedrich-Schiller-University Jena
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