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DOI: 10.1055/s-2002-19871
© Georg Thieme Verlag Stuttgart · New York
Antiplatelet and Anti-Inflammatory Constituents and New Oxygenated Xanthones from Hypericum geminiflorum
Publikationsverlauf
January 8, 2001
May 13, 2001
Publikationsdatum:
31. Januar 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200201/lookinside/thumbnails/10.1055-s-2002-19871-1.jpg)
Abstract
Two new pentaoxygenated xanthones, 2,3-dihydroxy-1,6,7-trimethoxyxanthone (1) and 3,6-dihydroxy-1,5,7-trimethoxyxanthone (2) were isolated from the leaf of Hypericum geminiflorum. The antiplatelet activities of the constituents, 2,6-dimethoxy-p-benzoquinone (3), gemichalcone A (4), gemichalcone B (5), and cycloartocarpin (6), of this plant, were assessed in vitro by determining their inhibitory effects on the aggregation of washed rabbit platelets induced by various inducers. The anti-inflammatory effects of 4 and 5 were assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells and neutrophils. Of the compounds tested, 4 exhibited the most potent inhibition of platelet aggregation induced by arachidonic acid (AA) and 4 and 5 strongly inhibited the release of β-glucuronidase and lysozyme in formyl-Met-Leu-Phe (fMLP)-stimulated rat neutrophils.
Key words
Hypericum geminiflorum - Clusiaceae - pentaoxygenated xanthone - antiplatelet - anti-inflammatory
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Associate Prof. Dr. M. I. Chung
Graduate Institute of Pharmaceutical Sciences
Kaohsiung Medical University
Kaohsiung 807
Taiwan
Republic of China
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