Abstract
Aims: Can a cut-off blood pressure level for major complications be identified?
Methods: A 10 years observation study in 385 type 2 diabetic patients.
Results: 158 patients were affected with myocardial infarction, stroke, renal failure or death,
which occurred in 68, 55, 19 and 109 patients, respectively. No patient with a blood
pressure below 140 mmHg and/or a diastolic blood pressure below 75 mmHg developed
uraemia during the observation period. No such cut-off level was seen for myocardial
infarction, stroke or death.
Conclusions: This study shows that there seems to be a cut-off level for blood pressure for development
of renal failure, while no level was found for cardio- or cerebrovascular disorders.
Key words
Blood Pressure - Mortality - Renal Failure - Myocardial Infarction - Stroke
References
- 1 UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular
and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998 317: 703-713
- 2
Agardh C-D, Agardh E, Torffvit O.
The prognostic value of albuminuria for the development of cardiovascular disease
and retinopathy: a 5-year follow-up study of 451 patients with type 2 diabetes mellitus.
Diab Res Clin Pract.
1996;
32
35-44
- 3
Sasaki A, Horiuchi N, Hasagawa K, Uehara M.
Persistent albuminuria as an index of diabetic nephropathy in type 2 diabetic patients
in Osaka, Japan - incidence, risk factors, prognosis and causes of death.
Diab Res Clin Pract.
1989;
7
299-306
- 4
MacLeod J M, Lutale J, Marshall S M.
Albumin excretion and vascular death in NIDDM.
Diabetologia.
1995;
38
610-616
- 5
Hanefeld M, Fischer S, Julius U, Schulze J, Schwanebeck U, Schmechel H. et al .
Risk factors for myocardial infarction and death in newly detected NIDDM: the Diabetes
Intervention Study, 11-year follow-up.
Diabetologia.
1996;
39
1577-1583
- 6
Walters D P, Gatling W, Houston A C, Mullee M A, Julious S A, Hill R D.
Mortality in diabetic subjects: an eleven-year follow-up of a community-based population.
Diabetic Med.
1994;
11
968-973
- 7
Niskanen L K, Parviainen M, Penttilä I, Uusitupa M IJ.
Evolution, risk factors, and prognostic implications of albuminuria in NIDDM.
Diabetes Care.
1996;
19
486-493
- 8
Standl E, Balletshofer B, Dahl B, Weichenhain B, Stiegler H, Hörmann A, Holle R.
Predictors of 10-year macrovascular and overall mortality in patients with NIDDM:
the Munich general practitioner project.
Diabetologia.
1996;
39
1540-1545
- 9
Damsgaard E M, Frøland A, Jørgensen O D, Mogensen C E.
Eight to nine year mortality on known non-insulin dependent diabetics and controls.
Kidney Int.
1992;
41
731-735
- 10
Hasslacher C, Bostedt-Kiesel A, Kempe H P, Wahl P.
Effect of metabolic factors and blood pressure on kidney function in proteinuric type
2 (non-insulin-dependent) diabetic patients.
Diabetologia.
1993;
36
1051-1056
O. Torffvit, M.D., Ph.D.
Department of Medicine · University Hospital
221 85 Lund · Sweden
Phone: + 46 (46) 2220702
Fax: + 46 (46) 2110908
Email: Ole.Torffvit@med.lu.se
