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Synthesis 2002(3): 0301-0314
DOI: 10.1055/s-2002-20030
DOI: 10.1055/s-2002-20030
REVIEW
© Georg Thieme Verlag Stuttgart · New YorkChemical Synthesis of ¹³ C and ¹5 N Labeled Nucleosides
Weitere Informationen
Received
8 October 2001
Publikationsdatum:
28. Juli 2004 (online)
Publikationsverlauf
Publikationsdatum:
28. Juli 2004 (online)
Abstract
The chemical synthesis of 13C and 15N labeled nucleosides for site-specific incorporation in RNA or DNA oligonucleotides is herein reviewed. The review covers the following aspects: 1: single- and multiple site chemical 13C and/or 15N labeling of purine bases, 2: single- and multiple site chemical 13C and/or 15N labeling of pyrimidine bases, 3: single- and multiple site chemical 13C labeling of the sugar residues.
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1 Introduction
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2 Enzymatic Synthesis of 13C/15N Labeled Bases and Nucleic Acids
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3 Synthesis of 13C/15N Labeled Purines
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3.1 Carbon and Nitrogen Labeling at the Level of the Bases
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3.2 Carbon and Nitrogen Labeling at the Nucleoside/Nucleotide Level
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4 Synthesis of 13C/15N Labeled Pyrimidines
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4.1 Synthesis of 13C/15N Labeled Uracil and Thymidine
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4.2 Synthesis of 13C/15N Labeled Cytosine
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5 13C Labeling of Sugars
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5.1 Uniformly 13C5 Labeling of Ribose
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5.2 Selective Carbon Labeling at the Sugar Moiety
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6 Conclusions
Key words
chemical synthesis - labeled nucleosides - 13C/15N labeling of nucleic bases - uniformly 13C labeling of sugars - selective 13C labeling of sugars
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