This study was conducted to evaluate the effects of the prenylated flavonol artocarpin from the heartwood of Artocarpus incisus on ultraviolet (UV)-induced hyperpigmentation of guinea pig skin. An efficient lightening effect was observed following topical application of artocarpin to UV-stimulated hyperpigmented dorsal skins of brownish guinea pigs.
References
1
Hearing V J, Tsukamoto K.
Enzymatic control of pigmentation in mammals.
FASEB Journal.
1991;
5
2902-9
2
Shimizu K, Kondo R, Sakai K, Lee S -H, Sato H.
The inhibitory components from Artocarpus incisus on melanin biosynthesis.
Planta Medica.
1998;
64
408-12
3
Dooley T P.
Topical skin depigmentation agents: current products and discovery of novel inhibitors of melanogenesis.
Journal of Dermatological Treatment.
1997;
8
275-9
5
Mishima Y, Ohyama Y, Shibata T, Seto H, Hatae S.
Inhibitory of kojic acid on melanogenesis and its therapeutic effect for various human hyper-pigmentation disorders (in Japanese).
Hifu (Skin Research).
1994;
36
134-50
6
Sato M, Fujiwara S, Tsuchiya H, Fujii T, Iinuma M, Tosa H, Ohkawa Y.
Flavones with antibacterial activity against cariogenic bacteria.
Journal of Ethnopharmacology.
1996;
54
171-6
7
Yokota T, Nishio H, Kubota Y, Mizoguchi M.
The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation.
Pigment Cell Research.
1998;
11
355-61
