Pneumologie 2002; 56(2): 113-131
DOI: 10.1055/s-2002-20093
Empfehlungen
Georg Thieme Verlag Stuttgart · New York

Empfehlungen zur Therapie des Bronchialkarzinoms

Gemeinsame Empfehlung der Deutschen Gesellschaft für Pneumologie (DGP), der Deutschen Gesellschaft für Radioonkologie (DEGRO), der Deutschen Gesellschaft für Thoraxchirurgie (DGT) und der Arbeitsgemeinschaft Internistische Onkologie in der Deutschen Krebsgesellschaft (AIO)Recommendations on the Therapy of Bronchial CarcinomaM.  Thomas,1 , M.  Baumann,1 , M.  Deppermann,1 , L.  Freitag,1 , U.  Gatzemeier,1 , R.  Huber,1 , B.  Passlick,1 , M.  Serke,1 , D.  Ukena,1
  • 1Klinik für Hämatologie, Onkologie und Pneumologie, Medizinische Klinik A, Universitätsklinikum Münster
Further Information

Publication History

Publication Date:
13 February 2002 (online)

Literatur

  • 1 Mountain C. Revisions in the international system for staging lung cancer.  Chest. 1997;  111 1710-1717
  • 2 Thomas M, Gatzemeier U, Goerg R, Matthiessen W, Morr H, Schönfeld N, Ukena D, Stamatis G. Empfehlungen zur Diagnostik des Bronchialkarzinoms.  Pneumologie. 2000;  54 361-371
  • 3 Pignon J P, Arriagada R, Ihde D C, Johnson D H, Perry M C, Souhami R L, Brodin O, Joss R A, Kies M S, Lebeau B. et al . A metaanalysis of thoracic radiotherapy for small cell lung cancer.  N Engl J Med. 1992;  327 1618-1624
  • 4 Warde P, Payne D. Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis.  J Clin Oncol. 1992;  10 890-895
  • 5 Murray N, Coy P, Pater J L, Hodson I, Arnold A, Zee B C, Payne D, Kostashuk E, Evans W, Dixon P, Sadura A, Feld R, Levitt M, Wierzbicki R, Ayoub J, Maroun J, Wilson K. Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer.  J Clin Oncol. 1993;  11 336-344
  • 6 Jeremic B, Shibamoto Y, Acimovic L, Milisavlejevic S. Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer. A randomized study.  J Clin Oncol. 1997;  15 893-899
  • 7 Goto K, Nishiwaki Y, Takada M, Fukuoka M, Kawahara M, Sugiara T, Kurita Y, Watanabe K, Noda K, Yoshimura K, Tamura T, Saijo N. Final results of a phase-III-study of concurrent versus sequential thoracic radiotherapy (TRT) in combination with cisplatin (P) and etoposide (E) for limited-stage small cell lung cancer (LD-SCLC). The Japan Clinical Oncology Group (JCOG) Study.  Proc Am Soc Clin Oncol. 1999;  18 468a (abs. 1805)
  • 8 Work E, Nielsen O, Bentzen S, Fode K, Palshof T. Randomized study of initial versus late chest irradiation combined with chemotherapy in limited-stage small-cell lung cancer.  J Clin Oncol. 1997;  15 3030-3037
  • 9 Perry M, Eaton W, Propert K, Ware J, Zimmer B, Chahinian P, Skarin A, Carey R, Kreisman H, Faulkner C, Comis R, Green M. Chemotherapy with or without radiation therapy in limited small-cell lung cancer.  N Engl J Med. 1987;  316 912-918
  • 10 Perry M, Herndon J, Eaton W, Green M. Thoracic radiation therapy added to chemotherapy in limited small cell lung cancer: an update of cancer and leukemia group B (CALGB) study 8083.  Proc Am Soc Clin Oncol. 1996;  15 384 (abs. 1150)
  • 11 Turrisi A, Kim K, Blum R, Sause W T, Livingston R B, Komaki K, Wagner H, Aisner S, Johnson D. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide.  N Engl J Med. 1999;  340 265-271
  • 12 Auperin A, Arriagada R, Pignon J P, Le Pechooux C, Gregor A, Stephens R J, Kristjansen P EG. Prophylactic cranial irridiation for patients with small-cell lung cancer in complete remission.  N Engl J Med. 1999;  341 476-484
  • 13 Shepherd F A, Ginsberg R J, Patterson G A, Evans W K, Feld R. A prospective study of adjuvant surgical resection after chemotherapy for limited small-cell lung cancer. A University of Toronto Lung Oncology Group Study.  J Thorac Cardiovasc Surg. 1989;  97 177-186
  • 14 Davis S, Crino L, Tonato M, Darwish S, Pelicci P G. A prospective analysis of chemotherapy following surgical resection of clinical stage I - II small-cell lung cancer.  Am J Clin Oncol. 1993;  16 93-95
  • 15 Karrer K, Shields T W, Denck H, Hrabar B, Vogt-Moykopf I, Salzer G M. The importance of surgical and multimodality treatment for small-cell bronchial carcinoma.  J Thorac Cardiovasc Surg. 1989;  97 168-176
  • 16 Kaiser D, Fritzsche A, Matthiessen W. Operationsindikation beim kleinzelligen Bronchialkarzinom.  Dtsch Med Wochenschr. 1992;  117 103-106
  • 17 Jeremic B, Shibamoto Y, Nicolic N, Milicic B, Milisavljevic S, Dagovic A, Aleksandrovic J, Radosavljevid-Asic G. Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer: a randomized study.  Journal of Clinical Oncology. 1999;  17 2092-2099
  • 18 Pearson F G, De Larue N C, Ilves R, Todd T R, Cooper J D. Significance of positive superior mediastinal nodes identified at mediastinoscopy in patients with resectable cancer of the lung.  J Thorac Cardiovasc Surg. 1982;  83 1-11
  • 19 Pitz C C, Brutel-de I R, Elbers H R, Westermann C J, van den Bosch J. Surgical treatment of 125 patients with non-small cell lung cancer and chest wall involvement.  Thorax. 1996;  51 846-850
  • 20 Gould P M, Bonner J A, Sawyer T E, Deschamps C, Lange C M, Li H. Patterns of failure and overall survival in patients with completely resected T3 N0 M0 non-small cell lung cancer.  Int J Radiat Oncol Biol Phys. 1999;  45 91-95
  • 21 Paulson D L. The role of preoperative radiation therapy in the surgical management of cacinoma in the superior pulmonary sulcus.  Front Radiat Ther Oncol. 1970;  5 177-187
  • 22 Ahmad K, Fayos J V, Kirsh M M. Apical lung carcinoma.  Cancer. 1984;  54 913-917
  • 23 Attar S, Krasna M J, Sonett J R, Hankins J R, Slawson R G, Suter C M, McLaughlin J S. Superior sulcus (Pancoast) tumor: experience with 105 patients [see comments].  Ann Thorac Surg. 1998;  66 193-198
  • 24 Paulson D L. Carcinomas in the superior pulmonary sulcus.  J Thorac Cardiovasc Surg. 1975;  70 1095-1104
  • 25 Maggi G, Casadio C, Pischedda F, Giobbe R, Cianci R, Ruffini E, Molinatti M, Mancuso M. Combined radiosurgical treatment of Pancoast tumor.  Ann Thorac Surg. 1994;  57 198-202
  • 26 Stuschke M, Heilmann H P. Lunge und Mediastinum. In: Scherer E, Sack H (Hrsg). Strahlentherapie, 4. Aufl. Berlin: Springer 1996: 683-718
  • 27 Arcasoy S M, Jett J R. Superior pulmonary sulcus tumors and pancoast syndrome.  N Engl J Med. 1997;  337 1370-1376
  • 28 Ichinose Y, Hara N, Ohta M, Yano T, Maeda K, Asoh H, Katsuda Y. Is T factor of the TNM staging system a predominat prognostic factor in pathologic stage I non-small cell lung cancer?.  J Thorac Cardiovasc Surg. 1993;  106 90-94
  • 29 Mountain C. New prognostic factors in lung cancer.  Chest. 1995;  108 246-254
  • 30 Cote R J, Beattie E J, Chaiwun B, Shi S R, Harvey J, Chen S C, Sherrod A E, Groshen S, Taylor C R. Detection of occult bone marrow micrometastases in patients with operable lung carcinoma.  Ann Surg. 1995;  222 415-425
  • 31 Passlick B, Kubuschok B, Izbicki J R, Thetter O, Pantel K. Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer.  Ann Thorac Surg. 1999;  68 2053-2058
  • 32 Thomas M, Macha H N, Rübe C, van de Loo J. Stellenwert der Chemotherapie in der Behandlung des nicht-kleinzelligen Bronchialkarzinoms.  Dtsch med Wschr. 1995;  120 1627-1630
  • 33 PORT. Meta-analysis Trialists Group . Postoperative radiotherapy in non-small-cell lung cancer: Systematic review and meta-analysis of individual patient data from 9 randomized controlled trials.  Lancet. 1998;  352 257-263
  • 34 Klages H T, Stuschke M. Postoperative Radiotherapie beim kurativ resezierten nicht-kleinzelligen Bronchialkarzinom.  Strahlenther Onkol. 1999;  175 134-138
  • 35 Rosell R, Gomez-Codina J, Camps C, Ryan M B, Putnam J B, Lee L S, Dhingra H, De Caro L, Chasen M, McGavran M, Atkinson E N, KiHong W. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer.  N Engl J Med. 1994;  330 153-158
  • 36 Roth J, Fossela F, Komaki R, Ryan M B, Putnam J B, Lee L S, Dhingra H, De Caro L, Chasen M, McGavran M, Atkinson E N, KiHong W. A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer.  J Natl Cancer Inst. 1994;  86 673-680
  • 37 Albain K S, Rusch V W, Crowley J J, Rice T W, Turrisi A T, Weick J K, Lonchyna V A, Presant C A, McKenna R J, Gandara D R, Fosmire H, Taylor S A, Stelzer K J, Beasley K R, Livingston R B. Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small cell lung cancer: mature results of Southwest Oncology Group phase II study 8805.  J Clin Oncol. 1995;  13 1880-1892
  • 38 Eberhardt W, Wilke H, Stamatis G, Stuschke M, Harstrick A, Menker H, Krause B, Müller M R, Stahl M, Flasshove M, Budach V, Greschuchna D, Konietzko N, Sack H, Seeber S. Preoperative chemotherapy followed by concurrent chemoradiation therapy based on hyperfractionated accelerated radiotherapy and definitive surgery in locally advanced non-small-cell lung cancer: mature results of a phase II trial.  J Clin Oncol. 1998;  16 622-634
  • 39 Thomas M, Rübe C, Semik M, von Eiff M, Freitag L, Macha H N, Wagner W, Klinke F, Sheld H H, Willich N, Berdel W E, Junker H. Chemotherapy and subsequent twice-daily chemoradiation before surgery in stage III non-small cell lung cancer: impact of tumor regression on survival.  J Clin Oncol. 1999 (a);  17 1185-1193
  • 40 Thomas M, Rübe C, Semik M, Steppling H, Macha H, Deimling A, Klinke F, Deppermann K, Clemens M, Dornoff W, Weber W, Berdel W. Randomized trial of chemotherapy and twice-daily chemoradiation versus chemotherapy alone before surgery in stage III non-small cell lung cancer: interim of toxicity.  Proc am Soc Clin Oncol. 1999 (b);  18 458a (abs. 1769)
  • 41 Dillman R O, Seagren S L, Propert K J, Guerra J, Eaton W L, Perry M C, Carey R W, Frei E F, Green M R. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer.  N Engl J Med. 1990;  323 940-945
  • 42 Le Chevalier T, Arriagda R, Quoix E, Ruffie P, Martin M, Tarayre M, Lacombe Terrier M J, Douillard J Y, Laplanche A. Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small cell lung cancer: First analysis of a randomized trial in 353 patients.  J Natl Cancer Inst. 1991;  83 417-423
  • 43 Le Chevalier T, Arriagda R, Tarayre M, Lacombe Terrier M J, Laplanche A, Quoix E, Ruffie P, Martin M, Douillard J Y. Significant effect of adjuvant chemotherapy on survival in locally advanced non-small cell lung carcinoma (letter).  J Natl Cancer Inst. 1992;  84 58
  • 44 Sause W T, Scott C, Taylor S, Johnson D, Livingstone R, Komaki R, Emami B, Curran W J, Byhardt R W, Turrisi A T, Dar A R, Cox J D. Radiation Therapy Oncology Group (RTOG) 80-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small cell lung cancer.  J Natl Cancer Inst. 1995;  87 198-205
  • 45 Sause W, Kolesar P, Taylor S, Johnson D, Livingston R, Komaki R, Emami B, Curran W, Byhardt R, Dar A, Turrisi A. Final results of phase III trial in regionally advanced non-small cell lung cancer. RTOG, ECOG and SWOG.  Chest. 2000;  117 358-364
  • 46 Dillman R O, Herndon J, Seagren S L, Eaton W L, Green M R. Improved survival in stage III non-small cell lung cancer: seven year follow up of CALGB 8433 trial.  J Natl Cancer Inst. 1996;  88 1210-1215
  • 47 American Society of Clinical Oncology . Clinical practice guidelines for the treatment of unresectable non-small-cell lung cancer.  J Clin Oncol. 1997;  15 2996-3018
  • 48 Choi N, Baumann M, Flentje M, Kellokumpu-Lehtinen P, Senan S, Zamboglou N, Kosmidis P. Predictive factors of radiation response in non-small cell lung cancer: present status.  Lung Cancer. 2001;  31 43-56
  • 49 Saunders M, Dische S, Barrett A, Harvey A, Gibson D, Parmar M. Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: a randomised multicenter trial.  Lancet. 1997;  350 161-165
  • 50 Schaake-Konig C, van den Bogaert W, Dalesio O, Festen J, Hoogenhout H, van Houtte P, Kirkpatrick A, Koolen M, Maat B, Nijs A, Renaud A, Rodrigus P, Schuster-Uitterhoeve L, Sculier J P, van Zandwijk N, Bartelink H. Effects of concomittand cisplatin and radiotherapy on inoperable non-small-cell lung cancer.  N Engl J Med. 1992;  326 524-530
  • 51 Jeremic B, Shibamoto L, Acimovic L, Djuric L. Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small cell lung cancer.  J Clin Oncol. 1995;  13 452-458
  • 52 Jeremic B, Shibamoto L, Acimovic L, Milisavljevic S. Hyperfractionated radiation therapy with or without concurrent low dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study.  J Clin Oncol. 1996;  14 1065-1070
  • 53 Furuse K, Fukuoka M, Kawahara M, Nishikawa H, Takada Y, Kudoh S, Katagami N, Ariyoshi Y. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with Mitomycin, Vindesine, and Cisplatin in unresectable stage III non-small lung cancer.  J Clin Oncol. 1999;  17 2692-2699
  • 54 Curran W, Scott C, Langer C, Komaki R, Lee J, Hauser S, Movsas B, Wassermann T, Rosenthal S, Byhardt R, Sause W, Cox J. Phase III comparison of sequential vs concurrent chemoradiation for pts with unresected stage III non-small cell lung cancer: Initial report of Radiation Therapy Oncology Group (RTOG) 9410.  Proc Am Soc Clin Oncol. 2000;  19 484a (abs. 1891)
  • 55 Saunders M, Dische S, Barrett A, Harvey A, Griffiths G, Parmar M. (on behalf of the CHART steering committee) . Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: mature data from the randomised multicentre trial.  Radiother Oncol. 1999;  52 137-148
  • 56 Baumann M. Accelerated radiation therapy in non-small cell lung cancer.  Radiother Oncol. 1999;  52 97-99
  • 57 Baumann M, Appold S, Zips D, Nestele U, Petersen C, Herrmann Th. Modified fractionation in the radical treatment of non-small cell lung cancer.  Front Radiat Ther Oncol. 2000;  34 80-88
  • 58 Baumann M, Herrmann T, Matthiessen W, Koch R, Strelocke K, Paul U. für das CHARTWEL-Bronchus Protokollkomitee (1997) CHARTWEL-Bronchus (ARO 97-1) . Eine randomisiert-multizentrische Studie zum Vergleich einer konventionell fraktionierten Strahlentherapie mit CHARTWEL-Bestrahlung bei inoperablen nicht-kleinzelligen Bronchialkarzinomen.  Strahlenther Onkol. 1997;  173 663-667
  • 59 Thomas M. Tumorassoziierte Prognoseparameter beim nicht-kleinzelligen Bronchialkarzinom.  Pneumologie. 1997;  51 669-677
  • 60 Thomas M, Rübe C, Semik M, von Eiff M, Klinke F, Macha H N, Freitag L, Scheld H H, Willich N, Berdel W E, Junker K. Trimodality therapy in stage III non-small cell lung cancer: prediction of recurrence by pretherapeutic assessment of p185neu.  Eur Respir J. 1999(c);  13 424-429
  • 61 Non-small cell lung cancer collaborative group . Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials.  BMJ. 1995;  311 899-909
  • 62 Le Chevalier T. Chemotherapy for advanced non-small cell lung cancer.  Chest. 1996;  109 107s-109s
  • 63 Ellis P A, Smith I, Hardy J, Nicolson M, Talbot D, Ashley S, Priest K. Symptom relief with MVP (mitomycin C, vinblastin and cisplatin) chemotherapy in advanced non-small cell lung cancer.  Br J Cancer. 1995;  71 366-370
  • 64 Thatcher N, Niven R M, Anderson H. Agressive versus nonaggressive therapy for metastatic non-small cell lung cancer.  Chest. 1996;  109 87s-92s
  • 65 Wirbel R J, Mutschler W E. Die chirurgische Therapie von Knochenmetastasen.  Zentralbl Chir. 1995;  120 707-715
  • 66 Janjan N A. Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticals.  Cancer. 1997;  80 1628-1645
  • 67 Sullivan F J. Palliative radiotherapy for lung cancer. In: Pass HI, Mitchell JB, Johnson DH, Turrisi AT (ed). Lung Cancer. Principles and Practice. Philadelphia-New York: Lippincott-Raven 1996: 775-789
  • 68 Berenson J R, Lichtenstein A, Porter L, Dimopoulos M A, Bordoni R, George S, Lipton A, Keller A, Ballester O, Kovacs M, Blacklock H, Bell R, Simeone J, Reitsma D, Heffernan M, Seaman J, Knight R. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma.  N Engl J Med. 1996;  334 488-493
  • 69 Hortobagyi G N, Theriault R L, Porter L, Blayney D, Lipton A, Sinoff C, Wheeler H, Simeone J F, Seaman J, Knight R D. Efficacy of pamidronate in reducing skeletal compliancations in patients with breast cancer and lytic bone metastases.  N Engl J Med. 1996;  335 1785-1791
  • 70 Theriault R L, Lipton A, Hortoagyi G N, Leff R, Glück S, Stewart J F, Costello S, Kennedy I, Simeone J, Seaman J J, Knight R D, Mellars K, Heffernan M, Reitsma D J. Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: A randomized, placebo-controlled trial.  J Clin Oncol. 1999;  17 846-854
  • 71 Ryan G F, Ball D L, Smith J G. Treatment of brain metastases from primary lung cancer.  Int J Radiat Oncol Biol Phys. 1995;  31 273-278
  • 72 Patchell R A, Tibbs P A, Walsh J W, Dempsey R J, Maruyama Y, Kryscio R J, Markesbery W R, Macdonald J S, Young B. A randomized trial of surgery in the treatment of single metastases to the brain.  N Engl J Med. 1990;  322 494-500
  • 73 Sause W T, Crowley J J, Morantz R, Rotman M, Mowry P A, Bouzaglou A, Borst J R, Selin H. Solitary brain metastasis: results of an RTOG/SWOG protocol evaluation surgery + RT versus RT alone.  Am J Clin Oncol. 1990;  13 427-432
  • 74 Cho K H, Hall W A, Gerbi B J, Higgins P D, Bohen M, Clark H B. Patient selection criteria for the treatment of brain metastases with sterotactic radiosurgery.  J Neurooncol. 1998;  40 73-86
  • 75 Flickinger J C, Lunsford L D, Somaza S, Konziolka D. Radiosurgery: its role in brain metastasis management.  Neurosurg Clin N Am. 1996;  7 497-504
  • 76 Dempke W, Behrmann C, Schöber C, Büchele T, Grothey A, Schmoll H-J. Diagnostisches und therapeuptisches Management der oberen Einflussstauung.  Med Klinik. 1999;  94 681-684
  • 77 Markman M. Diagnosis and management of superior vena cava syndrome.  Cleve Clin J Med. 1999;  66 59-61
  • 78 Ostler P J, Clarke D P, Watkinson A F, Gaze M N. Superior vena cava obstruction: a modern management strategy.  Clin Oncol R Coll Radiol. 1997;  9 83-89
  • 79 Hochrein J, Bashore T M, O'Laughin M P, Harrison K. Percutaneous stenting of superior vena cava syndrome: a case report and review of theliterature.  Am J Med. 1998;  104 78-84
  • 80 Nesbitt J C. Surgical management of superior vena cava syndrome. In: Pass HJ, Mitchell JB, Johnson DH, Turrisi AT (eds). Lung Cancer. Principles and Practice Philadelphia-New York: Lippincott-Raven 1996: 671-681
  • 81 Byrne T N. Spinal cord compression from epidural metastases.  N Engl J Med. 1992;  327 614-619
  • 82 Soerensen S, Helweg-Larsen S, Mouridsen H, Hansen H H. Effect of high-dose dexamethasone in carcinomateous metastatic spinal cord compression treated with radiotherapy: a randomised trial.  Eur J Cancer. 1994;  30A 22-27
  • 83 Bach F, Agerlin N, Sorensen J B, Rasmussen T B, Dombernowsky P, Sorensen P S, Hansen H H. Metastatic spinal cord compression secondary to lung cancer.  J Clin Oncol. 1992;  10 1781-1787
  • 84 Loblaw D A, Laperriere N J. Emergency treatment of malignant extradural spinal cord compression: an evidence-based guideline.  J Clin Oncol. 1998;  16 1613-1624
  • 85 Maranzano E, Latini P. Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial.  Int J Radiat Oncol Biol Phys. 1995;  32 959-967
  • 86 Solberg A, Bremnes R M. Metastatic spinal cord compression: diagnostic delay, treatment, and outcome.  Anticancer Res. 1999;  19 677-684
  • 87 Loddenkemper R. Thoracoscopy - state of the art.  Eur Respir J. 1998;  11 213-221
  • 88 Rodriguez-Panadero F, Antony V B. Pleurodesis: state of the art.  Eur Respir J. 1997;  10 1648-1654
  • 89 Hentrich M, Hartenstein R. Behandlung maligner Körperhöhlenergüsse.  Internist. 1997;  38 794-804
  • 90 Waller D A, Morritt G N, Forty J. Video-assisted thoracoscopic pleurectomy in the management of malignant pleural effusion.  Chest. 1995;  107 1454-1456
  • 91 Berg M, Heisel A, Ukena D, Schäfers H-J, Schieffer H. Behandlung des malignen Perikardergusses.  Med Klinik. 1997;  92 27-30
  • 92 Cherny N I, Portenoy R K. The management of cancer pain.  CA Cancer J Clin. 1994;  44 263-303
  • 93 World Health Organization [WHO] . Cancer pain relief. With a guide to opioid availability.  Cancer Pain Relief. 1996;  1-63
  • 94 Zech D F, Grond S, Lynch J, Hertel D, Lehmann K A. Validation of World Health Organization guidelines for cancer pain relief. A 10-year prospective study.  Pain. 1995;  63 65-76
  • 95 Bone Pain Trial Working Party . 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomized comparison with a multifraction schedule over 12 months of patient follow-up.  Radiother Oncol. 1999;  52 111-121
  • 96 Reichle G, Freitag L, Kullmann H J, Prenzel R, Macha H N, Farin G. Argon plasma coagulation in bronchology: a new method - alternative or complementary.  J Bronchol. 2000;  7 109-117
  • 97 Medical Research Concil Lung Cancer Working Party . A Medical Research Council (MRC) randomized trial of palliative radiotherapy with two fractions or a single fraction in patients with inoperable non-small-cell lung cancer (NSCLC) and poor performance status.  Br J Cancer. 1992;  65 934-941
  • 98 Medical Research Concil Lung Cancer Working Party . Randomized trial of palliative two-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small-cell lung cancer and good performance status.  Clinical Oncol. 1996;  8 167-175
  • 99 Speiser B L, Spratling L. Remote afterloading brachytherapy for the local control of endobronchial carcinoma.  Int J Radiation Oncology Biol Phys. 1993;  25 579-587
  • 100 Freitag L, Tekolf E, Stamatis G, Montag M, Greschuchna D. Three years experience with a new balloon catheter for the management of hemoptysis.  Europ Res J. 1994;  7 2033-2037
  • 101 Stoll J F, Bettmann M A. Bronchial artery embolization to control hemoptysis: a review.  Cardiovasc Intervent Radiol. 1988;  11 263-269
  • 102 Zhang J S, Cui Z P, Wang M Q, Yang L. Bronchial arteriography and transcatheter embolization in the management of hemoptysis.  Cardiovasc Intervent Radiol. 1994;  17 276-279
  • 103 Deutsche Gesellschaft für Pneumologie . Empfehlungen zur bronchoskopischen Behandlung tracheobronchialer Verschlüsse, Stenosen und muraler maligner Tumoren.  Pneumologie. 1998;  52 243-248
  • 104 Mathissen D J, Grillo H C. Endoscopic relief of malignant airway obstruction.  Ann Thorac Surg. 1998;  48 469-475
  • 105 Cavaliere S, Foccoli P, Tonielli C, Feijo S. Nd-YAF laser therapy in lung cancer. An 11 year experience with 2253 applications in 1585 patients.  J Bronchol. 1994;  1 105-111
  • 106 Macha H N, Becker K O, Kemmer H P. Pattern of failure and survival in endobronchial laser resection: a matched pair study.  Chest. 1994;  105 1668-1672
  • 107 Vergnon J M, Mathur P N. Cryotherapy for endobronchial disorders. In: Boliger CT, Mathur PN (Hrsg). Interventional Bronchoscopy Prog Respir Res Basel: Karger 2000 Vol 30: 133-145
  • 108 Sutedja G, van Boxem T J, Schramel F M, Felius v C, Postmus P E. Endobronchial electrocautery is an excellent alternative for Nd: YAG laser to treat airway tumors.  J Bronchol. 1997;  4 101-105
  • 109 Sutedja G, Bolliger C. Endothelial electrocautery and argon plasma coagulation. In: Bolliger CT, Mathur PN (Hrsg). Interventional Bronchoscopy Prog Respir Res Basel: Karger 2000 30: 120-132
  • 110 Maiwand M O, Homasson J P. Cryotherapy for tracheobronchial disorders. In: Mathur PN, Beamis JF (Hrsg). Clinics in Chest Medicine Philadelphia: Saunders 1995 Vol 16: 427-443
  • 111 Sutedja T G, Postmus P E. Photodynamic therapy in lung cancer. A review.  J Photochem Photobiol B. 1996;  36 199-204
  • 112 Freitag L, Korupp A, Itzigehl I, Dankwart F, Tekolf E, Reichle G, Kullmann H J, Macha H N. Erfahrungen mit Fluoreszenzdiagnostik und photodynamischer Therapie im multimodalen Behandlungskonzept des operierten rezidivierenden Bronchialkarzinoms.  Pneumologie. 1996;  50 693-699
  • 113 George P JM, Garrett C PO, Nixon C, Hetzel M R, Nanson E M, Millard F J. Laser treatment for tracheobronchial tumors: local or general anesthesia?.  Thorax. 1987;  42 656-660
  • 114 Macha H N, Wahlers B, Reichle G, von Zwehl D. Endobronchial radiation therapy for obstructing malignancies: ten years' experience with iridium-192 high-dose radiation brachytherapy afterloading technique in 365 patients.  Lung. 1995;  173 271-280
  • 115 Huber R M, Fischer R, Hautmann H, Pollinger B, Wendt T, Müller-Wening D, Häussinger K. Palliative endobronchial bradytherapy for central lung tumors. A prospective, randomized comparison of two fractionation schedules.  Chest. 1995;  107 463-470
  • 116 Huber R M, Fischer R, Hautmann H, Pollinger B, Häussinger K, Wendt T. Does additional brachytherapy improve the effect of external irradiation? A prospective, randomized study in central tumors.  Int J Radiat Oncol Biol Phys. 1997;  38 533-540
  • 117 Freitag L. Tracheobronchial stents. In: Bolliger CT, Mathur PN (Hrsg). Interventional Bronchoscopy Pro Respir Res Basel: Karger 2000 30: 171-186
  • 118 Sutedja G, Schramel F, van Kralingen K, Postmus P E. Stent placement is justifiable in endstage patients with malignant airway tumors.  Respiration. 1995;  62 148-150
  • 119 Silvestri G A, Handy J, Lackland D, Corley E, Reed C E. Specialists achieve better outcomes than generalists for lung cancer surgery [see comments].  Chest. 1998;  114 675-680
  • 120 Duque J L, Ramos G, Castrodeza J, Cerezal J, Castanedo M, Yuste M G, Heras F. Early complications in surgical treatment of lung cancer: a prospective, multicenter study. Grupo Cooperativo de Carcinoma Broncogenico de la Sociedad Espanola de Neumologia y Cirugia Toracica.  Ann Thorac Surg. 1997;  63 944-950
  • 121 Ginsberg R J, Hill L D, Eagan R T, Thomas P, Mountain C F, Deslauriers J, Fry W A, Butz R O, Goldberg M, Waters P F. Modern thirty-day operative mortality for surgical resections in lung cancer.  J Thorac Cardiovasc Surg. 1983;  86 654-658
  • 122 Warren W H, Faber L P. Segmentectomy versus lobectomy in patients with stage I pulmonary carcinoma.  J Thorac Cardiovasc Surg. 1994;  107 1087-1094
  • 123 Wahi R, McMurtrey M J, DeCaro L F, Mountain C F, Ali M K, Smith T L, Roth J A. Determinants of perioperative morbidity and mortality after pneumonectomy.  Ann Thorac Surg. 1989;  48 33-37
  • 124 Klemperer J, Ginsberg R J. Morbidity and mortality after pneumonectomy.  Chest Surg Clin N Am. 1999;  9 515-525
  • 125 Gaissert H A, Mathisen D J, Moncure A C, Hilgenberg A D, Grillo H C, Wain J C. Survival and function after sleeve lobectomy for lung cancer.  J Thorac Cardiovasc Surg. 1996;  111 948-953
  • 126 Bach P, Cramer L, Schrag D, Downey R, Gelfand S, Begg C. The influence of hospital volume on survival after resection of lung cancer.  N Engl J Med. 2001;  345 181-188
  • 127 Sugi K, Kaneda Y, Esato K. Video-assisted thoracoscopic lobectomy achieves a satisfactory long-term prognosis in patients with clinical stage IA lung cancer.  World J Surg. 2000;  24 27-30
  • 128 Naruke T, Tsuchiya R, Kondo H, Nakayama H, Asamura H. Lymph node sampling in lung cancer: how should it be done?.  Eur J Cardiothorac Surg. 1999;  16 Suppl 1 S17-S24
  • 129 McKenna-RJ J, Wolf R K, Brenner M, Fischel R J, Wurnig P. Is lobectomy by video-assisted thoracic surgery an adequate cancer operation?.  Ann Thorac Surg. 1998;  66 1903-1908
  • 130 Mack M J, Scruggs G R, Kelly K M, Shennib H, Landreneau R J. Video-assisted thoracic surgery: has technology found its place?.  Ann Thorac Surg. 1997;  64 211-215
  • 131 Bernard A. Resection of pulmonary nodules using video-assisted thoracic surgery. The Thorax Group.  Ann Thorac Surg. 1996;  61 202-204
  • 132 Mountain C, Dresler C. Regional lymphnode classification for lung cancer staging.  Chest. 1997;  111 1718-1723
  • 133 Passlick B, Thetter O. Lymph node documentation and lymphadenectomy in bronchial carcinomas. Results of a survey in Germany.  Chirurg. 1997;  68 601-605
  • 134 Schildberg F W, Dienemann H, Hoffmann H. Lymphadenektomie bei Bronchialkarzinomen: Fakten und Fiktion.  Zentralbl. 1996;  121 96-101
  • 135 Izbicki J R, Thetter O, Habekost M, Karg O, Passlick B, Kubuschok B, Busch C, Haeussinger K, Knoefel W T, Pantel K. Radical systematic lymphadenectomy in non-small cell lung cancer - A prospective controlled randomized clinical trial.  Brit J Surg. 1994;  81 229-235
  • 136 Izbicki J R, Passlick B, Pantel K, Pichlmeier U, Hosch S B, Karg O, Thetter O. Effectiveness of radical systematic mediastinal lymphadenectomy in patients with resectable non-small cell lung cancer - Results of a prospective randomized study.  Ann Surg. 1998;  227 138-144
  • 137 Luketich J D, Burt M E. Does resection of adrenal metastases from non-small-cell lung cancer improve survical?.  Ann Thorac Surg. 1996;  62 1614-1616
  • 138 Mussi A, Pistolesi M, Lucchi M. et al . Resection of single brain metastasis in non-small-cell lung cancer: prognostic factors.  J Thorac Cardiovasc Surg. 1996;  112 146-153
  • 139 Porte H L, Roumilhac D, Graziana J P. et al . Adrenalectomy for a solitary adrenal metastasis form lung cancer.  Ann Thorac Surg. 1998;  65 331-335
  • 140 Naruke T, Tsuchiya R, Kondo H, Asamura H, Nakayama H. Implications of staging in lung cancer.  Chest. 1997;  112 242S-248S
  • 141 Mountain C F. The biological operability of stage III non-small cell lung cancer.  Ann Thorac Surg. 1985;  40 60-64
  • 142 Inoue K, Sato M, Fujimara S, Sakurada A, Takahashi S, Usuda K, Kondo T, Tanita T, Handa M, Saito Y. Prognostic assessment of 1310 patients with non-small-cell lung cancer who underwent complete resection from 1980 to 1993.  J Thorac Cardiovasc Surg. 1998;  116 407-411
  • 143 Sagawa M, Sakurada A, Fujimara S, Sato M, Takahashi S, Usuda K, Endo C, Aikawa H, Kondo T, Saito Y. Five-year survivors with resected pN2 nonsmall cell lung carcinoma.  Cancer. 1999;  85 864-868
  • 144 Kreisman H, Wolkove N, Quoix E. Small cell lung cancer presenting as a solitary pulmonary nodule.  Chest. 1992;  101 225-231
  • 145 Fujimori K, Yokoyama A, Kurita Y, Terashima M. A pilot phase 2 study of surgical treatment after induction chemotherapy for resectable stage I to IIIA small cell lung cancer.  Chest. 1997;  111 1089-1093
  • 146 Elias A D. Small cell lung cancer: state-of-the-art therapy in 1996.  Chest. 1996;  112 251S-258S
  • 147 Osterlind K, Hansen M, Hansen H H, Dombernowsky P, Rorth M. Treatment policy of surgery in small cell carcinoma of the lung: retrospective analysis of a series of 874 consecutive patients.  Thorax. 1985;  40 272-277
  • 148 Lad T, Piantadosi S, Thomas P, Payne D, Ruckdeschel J, Giaccone G. A prospective randomized trial to determine the benefit of surgical resection of residual disease following response of small cell lung cancer to combination chemotherapy.  Chest. 1994;  106 320S-323S
  • 149 Fox W, Scadding J G. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-cell carcinoma of bronchus. Ten-year follow-up.  Lancet. 1973;  2 63-65
  • 150 Müler L C, Salzer G M, Huber H, Prior C, Ebner I, Frommhold H, Prauer H W. Multimodal therapy of small cell lung cancer in TNM stages I through IIIa.  Ann Thorac Surg. 1992;  54 493-497
  • 151 Eberhardt W, Stamatis G, Stuschke M, Wilke H, Muller M R, Kolks S, Flasshove M, Schutte J, Stahl M, Schlenger L, Budach V, Gerschuchna D, Stuben G, Teschler H, Sack H, Seeber S. Prognostically orientated multimodality treatment including surgery for selected patients of small-cell lung cancer patients stages IB to IIIB: long-term results of a phase II trial.  Br J Cancer. 1999;  81 1206-1212
  • 152 Armstrong J. Target volume definition for three-dimensional conformal radiation therapy of lung cancer.  Br J Radiol. 1998;  71 587-594
  • 153 Graham M V, Prudy J A, Emamai B, Harms W, Bosch W, Lockett M A, Perez C A. Clinical dose-volume histogramm analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC).  Int J Radiat Oncol Biol Phys. 1999;  45 323-329
  • 154 Marks L, Munley M T, Bentel G C, Zhou S M, Hollis D, Scarfone C, Sibley G, Kong F M, Jirtle R, Jaszczak R, Coleman R E, Tapson V, Anscher M. Physical and biological predictors of changes in whole lung function following thoracic irradiation.  Int J Radiat Oncol Biol Phys. 1997;  39 563-570
  • 155 Armstrong J, Raben A, Zelefsky M, Burt M, Leibel S, Burman C, Kutcher G, Harrison L, Hahn C, Ginsberg R, Rusch V, Kris M, Fuks Z. Promising survival with three-dimensional conformal radiation therapy for non-small cell lung cancer.  Radiother Oncol. 1997;  44 17-22
  • 156 De Ruysscher D, Vansteenkiste J. Chest radiotherapy in limited-stage small cell lung cancer: facts, questions, prospects.  Radiother Oncol. 2000;  55 1-9
  • 157 Royal College of Radiologists . Guidelines on the non-surgical management of lung cancer.  Clinical Oncology. 1999;  11 S1-S53
  • 158 Cox J, Azarnia N, Byhardt R W, Shin K H, Emami B, Pajak T F. A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.3 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83 - 11.  J Clin Oncol. 1990;  9 1543-1555
  • 159 Appold S, Baumann M, Neidt F, Herrmann T. Ergebnisse der Bestrahlung inoperabler nichtkleinzelliger Bronchialkarzinome im Stadium III mit 25 Gy in fünf Fraktionen.  Strahlenther Onkol. 1999;  175 267-270
  • 160 McQuay H J, Collins S L, Carroll D, Moore R A. Radiotherapy for the palliation of painful bone metastases.  Cochrane Database Syst Rev. 2000;  CD001793
  • 161 Coia L R, Aaronson N, Linggood R, Loeffler J, Priestman T J. A report of the consensus workshop panel on the treatment of brain metastases.  Int J Radiat Oncol Biol Phys. 1992;  23 223-227
  • 162 Koswig S, Budach V. Remineralisation und Schmerzlinderung von Knochenmetastasen nach unterschiedlich fraktionierter Strahlentherapie (10mal 3 Gy vs. 1 mal 8 Gy).  Strahlentherapie Onkol. 1999;  175 500-508
  • 163 Nestle U, Nieder C, Walter K, Abel U, Ukena D, Sybrecht G W, Schnabel K. A palliative accelerated irradiation regimen for advanced non-small-cell lung cancer vs. Conventionally fractionated 60 Gy: results of a randomized equivalence study.  Int J Radiat Oncol Biol Phys. 2000;  48 95-103
  • 164 Steenland E, Leer J, van Houwelingen H, Post W J, van den Hout W B, Kievit J, de Haes H, Martijn H, Oei B, Vonk E, van der Stehen-Banasik E, Wiggenraad R GJ, Hoogenhout J, Warlam-Rodenhuis C, van Tienhoven G, Wanders R, Pomp J, van Reijn M, van Mierlo T, Rutten E. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch bone metastasis study.  Radiother Oncol. 1999;  52 101-109
  • 165 Wolf M, Pritsch M, Drings P, Hans K, Schroeder M, Flechtner H, Heim M, Hruska D, Mende S, Becker H, Dannhäuser J, Lohmüller R, Gropp C, Gassel W D, Holle R, Havemann K. Cyclic-alternating versus response-oriented chemotherapy in small-cell-lung cancer: a German multicenter randomized trial of 321 patients.  J Clin Oncol. 1991;  9 614-624
  • 166 Murray N, Livingston R B, Shepherd F A, James K, Zee B, Langleben A, Kraut M, Bearden J, Goodwin J W, Grafton C, Turrisi A, Walde D, Croft H, Osoba D, Ottaway J, Gandara D. Randomized study of CODE versus alternating CAV/EP for extensive-stage small-cell lung cancer: an Intergroup Study of the National Cancer Institute of Canada Clincial Trials Group and the Southwest Oncology Group.  J Clin Oncol. 1999;  8 2300-2308
  • 167 Souhami R L, Rudd R, Ruiz de Elvira M C, James L, Gower N, Harper P G, Tobias J S, Partridge M R, Davison A G, Trask C, Spiro S G. Randomized trial comparing weekly versus 3-week chemotherapy in small-cell lung cancer: a Cancer Research Campaign trial.  J Clin Oncol. 1994;  12 1806-1813
  • 168 Arriagada R, Le Chevalier T, Pignon J P, Riviere A, Monnet I, Chomy P, Tuchais C, Tarayre M, Ruffie P. Initial chemotherapeutic doses and survival in patients with limited small-cell lung cancer.  N Engl J Med. 1993;  329 1848-1852
  • 169 Johnson D H, Carbone D P. Increased Dose-Intensity in Small-Cell Lung Cancer: A Failed Strategy?.  J Clini Oncol. 1999;  17 2297-2298
  • 170 Chute J P, Chen T, Feigal E, Simon R, Johnson D. Twenty years of Phase III Trials for Patients with Extensive-Stage Small-Cell Lung Cancer. Perceptible Progress.  J Clin Oncol. 1999;  17 1794-1801
  • 171 Kosmidis P A, Samantas E, Fountzilas G, Pavlidis N, Apostolopoulou F, Skarlos D. Cisplatin/etoposide versus carboplatin/etoposide chemotherapy and irradiation in small cell lung cancer: a randomized phase III study. Hellenic Cooperative Oncology Group for Lung Cancer Trials.  Semin Oncol. 1994;  21 23-30
  • 172 Medical Research Council Lung Cancer Working Party . Comparison of oral etoposide and standard intravenous multidrug chemotherapy for small-cell lung cancer. A stopped multicentre randomised trial.  Lancet. 1996;  348 563-566
  • 173 Medical Research Council Lung Cancer Working Party . Randomised trial of four-drug versus less intensive two-drug chemotherapy in the palliative treatment of patients with small cell lung cancer (SCLC) and poor prognosis.  B J Cancer. 1996;  73 406-413
  • 174 Ardizzoni A, Hansen H, Dombernowsky P, Gamucci T, Kaplan S, Postmus P, Giaccone G, Schaefer B, Wanders J, Verweij J. Topotecan an new drug in the second-line treatment of small-cell lung cancer: A phase II study of patients with refractory and sensitive disease.  J Clin Oncol. 1997;  15 2090-2096
  • 175 Groen H JM, Fokkema E, Biesma B, Kwa B, van Putten J WG, Postmus P E, Smit E F. Paclitaxel and Carboplatin in the Treatment of Small-Cell Lung Cancer Patients Resistant to Cyclophosphamide, Doxorubicin, and Etoposide: A Non-Cross-Resistant Schedule.  J Clin Oncol. 1999;  17 927-932
  • 176 von Pawel J, Schiller J H, Shephard F A, Fields S Z, Kleisbauer J P, Chrysson N G, Stewart D J, Clark P I, Palmer M C, Depierre A, Carmichael J, Krebs J B, Ross G, Lane S R, Gralla R. Topotecan Versus Cyclophosphamide, Doxorubicin, and Vincristine for the Treatment of Recurrent Small-Cell lung Cancer.  J Clin Oncol. 1999;  17 658-667
  • 177 Masuda N, Matusi K, Negoro S, Takifuji N, Takeda K, Yana T, Kobayashi M, Hirashima T, Kusunoki Y, Ushijima S, Kawase I, Tada T, Sawaguchi H, Fukuoka M. Combination of Irinotecan and Etoposide for treatment of refractory or relapsed small cell lung cancer.  J Clin Oncol. 1998;  16 3329-3334
  • 178 Ginsberg R, Vokes E, Raben A. Non-small cell lung cancer. In: DeVita V, Hellman S, Rosenberg S (Hrsg). Cancer Philadelphia: Lippincott-Raven 1997: 858
  • 179 Marino P, Preatoni A, Cantoni A, Bucceri G. Single-agent chemotherapy versus combination chemotherapy in advanced NSCLC. A quality and meta-analysis study.  Lung Cancer. 1995;  13 1-12
  • 180 Lilienbaum R C, Langenberg P, Dickersin K. Single agent chemotherapy versus combination chemotherapy in patients with advanced NSCLC: A meta-analysis of response, toxicity and survival.  Cancer. 1998;  82 116-126
  • 181 Perng R P, Chen Y M, Ming-Liu J, Tsai C M, Lin W C, Yang K Y, Whang-Peng J. Gemcitabine versus the combination of cisplatin and etoposide in patients with inoperable non-small-cell lung cancer in a phase II randomized study.  J Clin Oncol. 1997;  15 2097-2102
  • 182 Manegold C, Bergmann B, Chemaissani A, Dornhoff W, Drings P, Kellokumpu-Lehtinen P, Liippo K, Mattson K, von Pawel J, Ricci S, Sederholm C, Stahel R A, Wagenius G, van Walree N, ten Bokkel-Huinink W. Single agent gemcitabine versus cisplatin-etoposide: early results of a randomized phase II study in locally advanced or metastatic non-small cell lung cancer.  Ann Oncol. 1997;  8 525-529
  • 183 Frasci G, Lorusso V, Panza N, Comella P, Nicollela G, Bianco A, De Cataldis G, Ianelli A, Bilancia D, Belli M, Massidda B, Piantedosi F, Comella G, De Iena M. Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced NSCLC.  J Clin Oncol. 2000;  18 2529-2536
  • 184 The Elderly Lung Cancer Vinorelbine Italian Study Group (ELVIS) . Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer.  J Natl Cancer Inst. 1999;  91 66-72
  • 185 Larsen H, Sörensen J B, Nielsen A L, Dombernowsky P, Hansen H. Evaluation of the optimal duration of chemotherapy in phase II trials for inoperable NSCLC.  Ann Oncol. 1995;  6 993-997
  • 186 Smith I E, O'Brien M ER, Norton A, Ashley S, Webb A, Nicolson M, Hickish T, Talbot T, Mansi J. Duration of chemotherapy for advances NSCLC: A phase III randomized trial of 3 versus 6 courses of mitomycin, vinblastine, cisplatin (MVP).  Proc Am Soc Clin Oncol. 1998;  (abs. 1759)
  • 187 Giaccone G, Splinter T A, Debruyne C, Kho G S, Lianes P, van Zandwijk N, Penucci M C, Scagliotti G, van Meerbeeck J, van Hoesel Q, Curran D, Sahmoud T, Postmus P E. Randomized study of paclitaxel-cisplatin versus cisplatin-teniposide in patients with advanced non-small-cell lung cancer. The European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.  J Clin Oncol. 1998;  16 2133-2141
  • 188 Cardenal F, Lopez-Cabrerizo P, Anton A, Rosell R. Randomized phase III study of gemcitabine-cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastatic NSCLC.  J Clin Oncol. 1999;  17 12-18
  • 189 Le Chevalier T, Brisgand D, Douillard J, Pujol J, Alberola V, Monnier A, Riviere A, Lianes P, Chomy P, Cigolari S, Gottfried M, Ruffie P, Panizo A, Gaspard M, Ravaioli A, Besenval M, Besson F, Martinez A, Berthaud P, Tursz T. Randomized study of Vinorelbine and Cisplatin versus Vindesine and Cisplatin versus Vinorelbine alone in advanced non-small-cell lung cancer: Results of a European multicenter trial including 612 patients.  J Clin Oncol. 1994;  12 360-367
  • 190 Klasterski J, Sculier J, Lacoix H. et al . A randomized study comparing cisplatin or Carboplatin with etoposide in patients with advanced NSCLC. EORTC Protocol 07861.  J Clin Oncol. 1990;  8 1556-1562
  • 191 Biesma B, Smit E F, Postmus P E. A dose and schedule finding study of gemcitabine and etoposide in patients with progressive NSCLC after platinum containing chemotherapy.  Lung Cancer. 1999;  24 115-121
  • 192 Fossella F, DeVore R, Kerr R, Crawford J, Natale R, Dunphy F, Kalman L, Miller V, Lee J, Gandara D, Karp D, Vokes E, Kris M, Kim Y, Gamza S, Hammershaimb L. and the TAX 320 non-small cell lung cancer study group . Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small cell lung cancer previously treated with platinum-containing chemotherapy regimens.  J Clin Oncol. 2000;  18 2354-2362
  • 193 Shepherd F A, Dancey J, Ramlau R, Mattson K, Gralla R, O'Rourke M, Levitan N, Gressot L, Vincent M, Burkes R, Coughlin S, Kim Y, Berille J. Prospective randomized trial of Docetaxel versus best Supportive Care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy.  J Clin Oncol. 2000;  18 2095-2103
  • 194 Sutedja G, Postmus P E. Bronchoscopic treatment of lung tumors.  Lung cancer. 1994;  11 1-117
  • 195 Venmans B J, van Boxem T J, Smit E F, Postmus P E, Sutedja T G. Outcome of bronchial carcinoma in situ.  Chest. 2000;  117 1572-1576
  • 196 Sheski F D, Mathur P N. Endoscopic treatment of early-stage lung cancer.  Cancer Control. 2000;  7 35-44
  • 197 Koike T, Terashima M, Takizawa T, Tsukada H, Yokoyama A, Kurita Y, Honma K. Surgical results for centrally-located early stage lung cancer.  Ann Thorac Surg. 2000;  70 1176-1179
  • 198 Johnson B E. Second lung cancer in patients after treatment for an initial lung cancer.  J Natl Cancer Inst. 1998;  90 1335-1345
  • 199 Edell E S, Cotese D A. Photodynamic therapy in the management of early superficial squamous cell carcinoma as an alternative to surgical resection.  Chest. 1992;  102 1319-1322
  • 200 Perol M, Caliandro R, Pommier P, Malet C, Montbarbon X, Carrie C, Ardiet J M. Curative irradiation of limited carcinomas with high-dose brachytherapy.  Chest. 1997;  111 1417-1423
  • 201 van Boxem T J, Venmans B J, Schramel F M, van Mourik J C, Golding R P, Postmus P E, Sutedja T G. Radiographically occult lung cancer treated with fibreoptic bronchoscopic electrocautery: a pilot study of a simple and inexpensive technique.  Eur Respir J. 1998;  11 169-172
  • 202 Deygas N, Froudarakis M E, Ozenne G, Jouve S, Fournel P, Vergnon J M. Cryotherapy in early superficial bronchogenic carcinoma.  Eur Respir J. 1998;  12 (Suppl 28) 266
  • 203 Furuse K, Fukuoka M, Kato H, Horrai T, Kubota T, Kodama N, Kusunoki Y, Takifuji N, Okunaka T, Konaka C, Wada H, Hayata Y. A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer.  J Clin Oncol. 1993;  11 1852-1857
  • 204 Kato H, Okunaka T, Shimatani H. Photodynamic therapy for early stage bronchogenic carcinoma.  J Clin Laser Med Surg. 1996;  14 235-238
  • 205 Cortese D A, Edell E S, Kinsey J H. Photodynamic therapy for early stage squamous cell carcinoma of the lung.  Mayo Clin Proc. 1997;  72 595-602
  • 206 Martini N. Surgical treatment of non-small cell lung cancer by stage.  Semin Surg Oncol. 1990;  6 248-254
  • 207 Kotlyarov E, Rukosuyev A A. Long-term results and patterns of disease recurrence after radical operations for lung cancer.  J Thorac Cardiovasc Surg. 1991;  102 24-28
  • 208 The Lung Cancer Study Group . Patterns of failure in patients with resected stage I und II non-small cell carcinoma of the lung.  Ann Surg. 1987;  205 67
  • 209 Pairolero P C, Williams D E, Bergstralh E J, Piehler J M, Bernatz P E, Payne W S. Postsurgical stage I bronchogenic carcinoma: morbid implications of recurrent disease.  Ann Thorac Surg. 1984;  38 331-338

Priv.-Doz. Dr. med. M. Thomas

Klinik für Hämatologie, Onkologie und Pneumologie Medizinische Klinik A, Universitätsklinikum Münster

Albert-Schweizer Str. 33

48149 Münster

Email: mthomas@uni-muenster.de

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