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DOI: 10.1055/s-2002-20244
© Georg Thieme Verlag Stuttgart · New York
Marked Decrease of Cyclosporin Absorption Caused by Phellamurin in Rats
Publikationsverlauf
February 23, 2001
May 24, 2001
Publikationsdatum:
22. Februar 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200202/lookinside/thumbnails/10.1055-s-2002-20244-1.jpg)
Abstract
Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). In vitro everted rat intestine study indicated that phellamurin inhibited intestinal P-glycoprotein in a dose-dependent manner. In order to investigate the effect of phellamurin on cyclosporin absorption and disposition, rats were given cyclosporin (5 mg/kg) with or without phellamurin in a parallel design. Fluorescence polarization immunoassay was used to determine the blood concentration of cyclosporin. Unanticipatedly, our results indicated that the coadministration of phellamurin significantly decreased the Cmax of cyclosporin by 77 % and reduced the AUC0-∞ of cyclosporin by 56 %. This indicated that a serious interaction occurred between phellamurin with cyclosporin. To ensure the efficacy of cyclosporin, we suggest that the coadministration of phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
Key words
Phellamurin - cyclosporin - pharmacokinetic interaction - Phellodendron wilsonii - Rutaceae - flavonoid
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Prof. Pei-Dawn Lee Chao
Dept. of Pharmacy
China Medical College
Taichung
Taiwan 404
R. O. C
Fax: +886-4-22031028
eMail: pdlee@mail.cmc.edu.tw