RSS-Feed abonnieren
DOI: 10.1055/s-2002-20249
© Georg Thieme Verlag Stuttgart · New York
Nematocidal Activity of Isoquinoline Alkaloids Against a Species of Diplogastridae
Publikationsverlauf
March 1, 2001
June 3, 2001
Publikationsdatum:
22. Februar 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200202/lookinside/thumbnails/10.1055-s-2002-20249-1.jpg)
Abstract
We examined the nematocidal activity of various isoquinoline alkaloids. The method of evaluating nematocidal activity involved the microscopic examination of the state of larvae after the compound was administered to determine the minimum lethal concentration (MLC). In addition, cytotoxic activity (IC50) was examined using HL-60 culture cells. The compound dehydrocorydaline was found to have considerable nematocidal activity and weak cytotoxicity; its cytotoxicity value was equal to that of thiabendazole. We conclude that dehydrocorydaline, with its attractive balance between nematocidal activity and weak cytotoxicity, is the most promising of the tested compounds as a possible remedy for parasitic diseases.
References
- 1 Alba-Hurtado F, Tórtora P JL, Tsutsumi V, Ortega-Pierres M G. Histopathological investigation of experimental ocular toxocariasis in gerbils. International Journal for Parasitology. 2000; 30 143-7
- 2 Yanagida J, Matsuhashi R, Watanabe I, Satou T, Koike K, Nikaido T, Akao S. A new subculture and nematocidal assay using a species of Diplogastridae. Chemical & Pharmaceutical Bulletin. 1998; 46 1261-4
- 3 Watanabe I, Koike K, Satou T, Nikaido T. Nematocidal activity of picrodendrins against a species of Diplogastridae. Biological & Pharmaceutical Bulletin. 1999; 22 1310-3
- 4 Watanabe I, Koike K, Satou T, Nikaido T. Nematocidal activity of quassinoids against a species of Diplogastridae. Biological & Pharmaceutical Bulletin. 2000; 23 723-6
- 5 Hanaoka M, Motonishi T, Mukai C. Chemical transformation of protoberberines part 9. A biomimetic synthesis of oxychelerythrine dihydrochelerythrine and chelerythrine from berberine. Journal of the Chemical Society. Perkin Transactions I. 1986; 12 2253-6
- 6 Itokawa H, Ikuta A, Tsutsui N, Ishiguro I. Alkaloids and a sterol from Chelidonium japonicum . Phytochemistry. 1978; 17 839-40
- 7 Pandey V B, Ray A B, Dasgupta B. Minor alkaloids of Fumaria indica seeds. Phytochemistry. 1979; 18 695-6
- 8 Zhang G L, Rucker G, Breitmaier E, Mayer R. Alkaloids from Hypecoum leptocarpum . Phytochemistry. 1995; 40 1813-6
- 9 Blanco O, Castedo L, Cortes D, Villaverde C. Alkaloids from Sarcocapnos saetabensis . Phytochemistry. 1991; 30 2071-4
- 10 Matsuda , Tokuoka K, Wu J, Shiomoto H, Kubo M. Inhibitory effects of dehydrocorydaline isolated from Corydalis tuber against type I-IV allergic models. Biological & Pharmaceutical Bulletin. 1997; 20 431-4
- 11 Jewers K, Manchanda A H. The proton magnetic resonance spectra of protoberberinium salts. Journal of the Chemical Society,. Perkin Transactions. 1972; II 1393-6
- 12 Imaseki I, Taguchi H. Studies on the components of Corydalis spp. I. Alkaloids of Chinese Corydalis. On the new bases corydalmine and dehydrocorydalmine. Yakugaku Zasshi. 1961; 82 1214-9
- 13 Hanaoka M, Yoshida S, Mukai C. Chemical transformation of protoberberines. XV. A novel and efficient method for the introduction of alkyl groups on C-13 position in the protoberberine skeleton. Chemical & Pharmaceutical Bulletin. 1989; 37 3264-7
- 14 Taguchi H, Imaseki I. Studies on the components of Corydalis spp. II. Alkaloids of Corydalis ambigua Cham. et Schlecht. var. amurensis Maxim. (1). On tertiary alkaloids. Yakugaku Zasshi. 1963; 83 578-81
- 15 Sargent J M, Taylor C G. Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukemia. British Journal of Cancer. 1989; 60 206-10
Tamotsu Nikaido
Department of Pharmacognosy
School of Pharmaceutical Sciences
Toho University
2-2-1 Miyama
Funabashi
Chiba 274-8510
Japan
eMail: nikaido@phar.toho-u.ac.jp
Telefon: +81-47-472-1391
Fax: +81-47-472-1404