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DOI: 10.1055/s-2002-20257
© Georg Thieme Verlag Stuttgart · New York
Constituents of the Leaves and Twigs of Ficus hispida
Publication History
March 16, 2001
June 24, 2001
Publication Date:
22 February 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200202/lookinside/thumbnails/10.1055-s-2002-20257-1.jpg)
Abstract
A new norisoprenoid, ficustriol (1), and the known phenanthroindolizidine alkaloid O-methyltylophorinidine (2), were isolated from a CHCl3 extract of the leaves and twigs of Ficus hispida. O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods.
References
- 1 Condit I J. Ficus: the Exotic Species. University of California Press Riverside, CA; 1969: 81-3
-
2 Corner E JH. Moraceae. In: Dassanayake MD, Fosberg FR, editors
Flora of Ceylon . Vol. 3 Amerind Publishing Co New Delhi; 1981: 213-92 - 3 Venkatachalam S R, Mulchandani N B. Isolation of phenanthroindolizidine alkaloids and a novel biphenylhexahydroindolizidine alkaloid from Ficus hispida . Naturwissenschaften. 1982; 69 287-8
- 4 Bhar P, Thakur S. Hydrocarbons from the leaves of Ficus hispida Roxb., Ficus bengualensis L. and Ficus infectoria L. Indian Journal of Chemistry. 1981; 20B 722-3
- 5 Acharya B M, Kumar K A. Chemical examination of the bark of Ficus hispida L. Current Science. 1984; 53 1034-5
- 6 El-Khrisy E AM, Khattab A A, Abu-Mustafa E A. Constituents of Ficus asprima, F. hispida and F. carica . Fitoterapia. 1980; 51 269-72
- 7 Govindachari T R, Viswanathan N, Radhakrishnan J, Pai B R, Natarajan S, Subramaniam P S. Minor alkaloids of Tylophora asthmatica. Revised structure of tylophorinidine. Tetrahedron. 1973; 29 891-7
- 8 Govindachari T R, Viswanathan N, Pai B R. Stereochemistry of tylophorinidine and tylophorinine. Indian Journal of Chemistry. 1974; 12 886-7
- 9 Mulchandani N B, Venkatachalam S R. Alkaloids of Pergularia pallida . Phytochemistry. 1976; 15 1561-3
- 10 Takagi Y, Fujimori T, Kaneko H, Fukuzumi T, Noguchi M. Isolation of a new tobacco constituent, (3S,5R,6S,9ε)-3-hydroxy-5,6-epoxy-β-ionol), from Japanese domestic SUIFU tobacco. Agricultural and Biological Chemistry. 1978; 42 1785-7
- 11 Ohtani I, Kusumi T, Kashman Y, Kakisawa H. High-field FT-IR application of Mosher’s method. The absolute configuration of marine terpenoids. Journal of the American Chemical Society. 1991; 113 4092-6
- 12 Peraza-Sánchez S R, Chávez D, Chai H -B, Shin Y G, García R, Mejía M, Fairchild C R, Lane K E, Menendez A T, Farnsworth N R, Cordell G A, Pezzuto J M, Kinghorn A D. Cytotoxic constituents of the roots of Ekmanianthe longiflora . Journal of Natural Products. 2000; 63 492-5
- 13 Likhitwitayawuid K, Angerhofer C K, Cordell G A, Pezzuto J M, Ruangrungsi N. Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta . Journal of Natural Products. 1993; 56 30-8
Prof. A. Douglas Kinghorn, Ph. D., D.Sc.
Program for Collaborative Research in the Pharmaceutical Sciences
and Department of Medicinal Chemistry and Pharmacognosy
College of Pharmacy
University of Illinois at Chicago
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Chicago
IL 60612
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Email: address: kinghorn@uic.edu.