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Planta Med 2002; 68(2): 162-163
DOI: 10.1055/s-2002-20258
Letter

© Georg Thieme Verlag Stuttgart · New York

Inhibitors of 5α -Reductase Type I in LNCaP Cells from the Roots of Angelica koreana

Eun-Kyoung Seo1 , Kyeong Ho Kim2 , Min Ki Kim2 , Myung-Haing Cho3 , EunWook Choi4 , KiNam Kim4 , Woongchon Mar4
  • 1Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea
  • 2College of Pharmacy, Kangwon National University, Chunchon, Korea
  • 3NIAST, RDA and College of Veterinary Medicine, Seoul National University, Suwon, Korea
  • 4Natural Products Research Institute, Seoul National University, Seoul, Korea
Further Information

Publication History

April 19, 2001

June 24, 2001

Publication Date:
22 February 2002 (online)

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Abstract

A prenylated coumarin, osthenol (1) and a sesquiterpene, bisabolangelone (2) have been isolated as active principles with 5α-reductase type I inhibitory effects in LNCaP cells from the roots of Angelica koreana Max. by bioassay-guided chromatographic fractionation. Osthenol exhibited a highly potent inhibitory activity on 5α-reductase type I in LNCaP cells with an IC50 value of 0.1 μg/ml, which is about 200 times more potent than the positive control, finasteride (IC50 = 19.8 μg/ml). Bisabolangelone also inhibited the activity of 5α-reductase type I in LNCaP cells (IC50 = 11.6 μg/ml), indicating that these compounds are possible candidates for the development of new drugs to treat human endocrine disorders associated with overproduction of DHT by 5 α-reductase type I. In addition, four compounds isooxypeucedanin, oxypeucedanin hydrate, oxypeucedanin and isoimperatorin were also isolated and found to be inactive in the 5α-reductase assay systems used in the present study.

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Prof. Ph. D. Woongchon Mar

Natural Products Research Institute

Seoul National University

Seoul 110-460

Korea

Phone: +82-2-740-8911

Fax: +82-2-3672-5488

Email: mars@snu.ac.kr