Regioselective Hydroxylation of 2,4-Lutidine: A Practical Synthesis of 4-Hydroxymethyl-2-methylpyridine

John A. Ragan; Brian P. Jones; Clifford N. Meltz; John J. Teixeira

doi:10.1055/s-2002-20960

PAPER

Regioselective Hydroxylation of 2,4-Lutidine: A Practical Synthesis of 4-Hydroxymethyl-2-methylpyridine

John A. Ragan*, Brian P. Jones, Clifford N. Meltz, Jr. John J. Teixeira
Chemical Research and Development, Pfizer Global Research & Development, P.O. Box 8156-101, Groton, CT 06340, Canada
Fax: +1(860)4416334; e-Mail: john_a_ragan@groton.pfizer.com;

Abstract

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Abstract

A practical synthesis of 4-hydroxymethyl-2-methylpyridine has been developed which makes use of Evans’ regioselective lithiation of readily available 2,4-lutidine and trapping with dimethylformamide.

Key words

lithiation - hydroxylation - regioselectivity - pyridines

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Referenzen

References

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