Abstract
The anodic oxidation of phenol derivatives generates radical and cationic species, which upon coupling with other radicals, nucleophiles, and dienophiles provide a variety of bioactive natural products. The reaction conditions are controlled by electric potentials, solvents, supporting salts, electrodes, and so on to obtain the desired products. Both single- and two-electron reactions have been studied. The application of these reactions towards the synthesis of several target molecules will be discussed here.
1 Introduction
2 Single-electron Oxidation
2.1 Radical Coupling to C-C and C-O Bonds
2.2 Phenolic Oxidation of Bromophenols Towards Bioactive
Natural Products
3 Two-electron Oxidation
3.1 Cationic Reaction
3.2 [4+2] Cycloaddition
3.3 [3+2] Cycloaddition
3.4 [5+2] Cycloaddition
3.5 Intramolecular [5+2] Cycloaddition
4 Conclusion
Key words
anodic oxidation - bioactive natural products - single-electron oxidation - two-electron oxidation
