Abstract
The CHCl3-soluble part (HJ) of the MeOH extract from Hypericum japonicum afforded new bisxanthones, jacarelhyperols A (1) and B (2). The structures were elucidated by spectral methods. These compounds and HJ showed significant inhibitory effects against PAF-induced hypotension by an in vivo evaluation method, which can reveal the pharmacological action of the test material.
Abbreviations
PAF:platelet-activating factor
HEL:hen egg-white lysozyme
CV 3988:rac-3-(N-n-octadecyl carbamoyloxy)-2-methoxypropyl2-thiazoliethyl phosphate
Key words
Hypericum japonicum Thunb. - Clusiaceae - PAF antagonist - bisxanthones - jacarelhyperols A and B
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1 * Part 10 in the series; for part 9 see ref. [3].
Dr. Kyoko Ishiguro
School of Pharmaceutical Sciences
Mukogawa Women's University
Koshien Kyuban-cho
Nishinomiya
Hyogo 663-8179
Japan
Email: ishiguro@mwu.mukogawa-u.ac.jp
Fax: +81 798-41-2792