Planta Med 2002; 68(3): 262-265
DOI: 10.1055/s-2002-23131
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Benzophenanthridine Alkaloids from Corydalis flabellata

Summon Koul1 , T. K. Razdan1 , C. S. Andotra1 , A. K. Kalla1 , S. Koul2 , S. C. Taneja2
  • 1Department of Chemistry, University of Jammu, Ambedkar Road, Jammu, India
  • 2Regional Research Laboratory, Canal Road, Jammu, India
Weitere Informationen

Publikationsverlauf

March 29, 2001

July 9, 2001

Publikationsdatum:
25. März 2002 (online)

Abstract

Four new alkaloids, characterized as 6-(2-hydroxyethyl)-5,6-dihydrosanguinarine (1), 6-acetonyl-5,6-dihydrosanguinarine (2), N-methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenanthridine-6-ethanoic acid (3), N-methyl-2,3,7,8-tetramethoxy-6-oxo-5,6-dihydrobenzophenanthridine (4), together with oxosanguinarine (5), spallidamine (6), 6-acetonyl-5,6-dihydrochelerythrine (7), 6-oxochelerythrine (8) and sanguidimerine (9) were isolated from the roots of Corydalis flabellata.

References

  • 1 Shamma M, Moniot J L. Isoquinoline Alkaloid Research. Plenum Press New York; 1978
  • 2 Dhar U, Kachroo P. Alpine Flora of Kashmir Himalaya. Scientific Publications Jaipur, India; 1983: p. 115
  • 3 Shah G N, Zaman A, Khan M A, Gray A I, Provan G J, Waterman P G, Sadler I H. (±) Severzinine from Corydalis flabellata: Interpretation of NMR spectra.  J. Natural Products. 1989;  52 1027-9
  • 4 Tin-Wa M, Fong H HS, Abraham D J, Trojanek J, Farnsworth N R. Structure of sanguidimerine, a new major alkaloid from Sanguinaria canadensis (Papaveraceae).  J. Pharm Sciences. 1972;  61 1846-8
  • 5 Ma W G, Fukushi Y, Tahara S. Fungitoxic alkaloids from Hokkaido Corydalis species.  Fitoterapia. 1999;  70 258-61
  • 6 Kim H K, Farnsworth N R, Blomsten R N, Fong H HS. Biological and phytochemical evaluation of plants V: Isolation of two cytotoxic alkaloids from Chelidonium majus .  J. Pharm Sciences. 1969;  58 372-6
  • 7 Slavik J, Dolejs L, Hanus V, Cross A D. Alkaloids of Papaveraceae XI. Chelirubine, chelilutine, sanguirubine and sanguilutine, mass and nuclear magnetic resonance spectra of benzophenanthridine alkaloids.  Collect. Czech. Chem. Commun.. 1968;  33 1619-24
  • 8 McLean D B, Gracy D EF, Saunders J K, Rodrigo R, Manske R HF. Some benzophenanthridine alkaloids from Bocconia arborea .  Canadian J. Chem.. 1969;  47 1951-4
  • 9 Albright J D, Goldman L. Dimethyl sulfoxide-acid anhydride mixtures for the oxidation of alcohols.  J. Am. Chem. Soc.. 1967;  89 2416
  • 10 Furuya T, Ikuta A, Syono K. Alkaloids from callus tissue of Papaver somniferum .  Phytochemistry. 1972;  11 3041-4
  • 11 Yamaguchi K. Spectra data of natural products. Elsevier New York; 1970: p. 551-4
  • 12 Ito C, Mizuno T, Wu T S, Furakawa H. Alkaloids from Corydalis .  Phytochemistry. 1990;  29 2044-5

T. K. Razdan

Department of Chemistry

University of Jammu

Ambedkar Road

Jammu-180006

India

eMail: tk_razdan@rediff.comm