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Planta Med 2002; 68(3): 274-277
DOI: 10.1055/s-2002-23138
Letter

© Georg Thieme Verlag Stuttgart · New York

Croblongifolin, a New Anticancer Clerodane from Croton oblongifolius

Sophon Roengsumran1 , Kusalin Musikul1 , Amorn Petsom1, 3 , Tirayut Vilaivan1 , Polkit Sangvanich1 , Surachai Pornpakakul1 , Songchan Puthong3 , Chaiyo Chaichantipyuth2 , Nongnuj Jaiboon1 , Narongsak Chaichit4
  • 1Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • 2Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
  • 3Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, Thailand
  • 4Department of Physics, Faculty of Science and Technology, Thammasat University Rangsit, Pathum Thani, Thailand
Further Information

Publication History

April 4, 2001

August 21, 2001

Publication Date:
25 March 2002 (online)

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Abstract

A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.

References

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Sophon Roengsumran

Department of Chemistry

Faculty of Science

Chulalongkorn University

Bangkok

10330 Thailand

Fax: +66-2-253-0321

Email: amorn.p@chula.ac.th