Horm Metab Res 2002; 34(3): 121-126
DOI: 10.1055/s-2002-23194
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Effects of 5-Campestenone (24-Methylcholest-5-en-3-one) on the Type 2 Diabetes Mellitus Model Animal C57BL/KsJ-db/db Mice

K.  Suzuki 1, 2 , M.  Tanaka 2 , R.  Konno 2 , Y.  Kaneko 2
  • 1Obesity and Lipidemia Research Unit, RIKEN, Wako, Japan
  • 2Japan Science and Technology Corporation, Tokyo, Japan
Further Information

Publication History

20 August 2001

11 December 2001

Publication Date:
26 March 2002 (online)

Summary

We examined the therapeutic effects of dietary exposure to 5-campestenone (24-methylcholest-5-en-3-one), an enone derivative of campesterol, in C57BL/KsJ-db/db mice, which are an animal model of obese type 2 diabetes. Blood glucose levels of db/db mice linearly increased from 270 to 720 mg/dl in 10 weeks, an approximately 7-fold difference from the levels of db/+m mice. The 0.3 % dietary exposure to 5-campestenone caused a marked reduction in blood glucose levels of 330 mg/dl after 10 weeks of feeding with a concomitant inhibition of glucose excretion in urine. Only slight efficacy was observed with 0.1 % dietary exposure to this chemical in db/db mice. Significant decreases of plasma triglyceride and plasma free fatty acid were also observed in db/db mice at a 0.3 % dose. However, feed efficiency and body-weight gain in db/db mice was improved by 5-campestenone. No obvious anomaly due to consumption of 5-campestenone was detected by necropsy or clinical observation.

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Kunio Suzuki

Obesity and Lipidemia Research Unit · RIKEN Institute

Wako · Saitama 351-0198 · Japan