Subscribe to RSS
DOI: 10.1055/s-2002-23537
Synthesis of Enantiomerically Pure 8-Substituted 5,6,7,8-Tetrahydroquinolines
Publication History
Publication Date:
02 April 2002 (online)

Abstract
Enantiomerically pure (S)-5,6,7,8-tetrahydroquinolin-8-ol [(S)-1] and (R)-8-acetoxy-5,6,7,8-tetrahydroquinoline [(R)-2] have been prepared by the lipase-catalyzed kinetic acetylation of racemic 5,6,7,8-tetrahydroquinolin-8-ol [(±)-1] in excellent chemical yields. The mesylation of (R)-1 followed by a substitution reaction with the azide, thioacetate, and dimethyl malonate anions and benzylamine gives the corresponding substituted products in an enantiomerically pure form with an inversion of the configuration in good yields. The methanolysis of (S)-5,6,7,8-tetrahydroquinolin-8-yl acetate in the presence of potassium carbonate and alkylation of the resulting thiol anion with alkyl halides in a one-pot reaction gives the 5,6,7,8-tetrahydroquinolin-8-yl thioether.
Key words
8-substituted quinolines - enzymatic acetylation - nucleophiles - stereospecific substitutions - asymmetric synthesis
- 1
Comprehensive Heterocyclic Chemistry
Vol. 2:
Boulton AJ.Mckillop A. Pergamon; Oxford: 1984. -
2a
Kees KL.Smith TM.McCaleb ML.Prozialeck DH.Cheeseman RS.Christos TE.Patt WC.Steiner KE. J. Med. Chem. 1992, 35: 944 -
2b
Beattie DE.Crossley R.Curran ACW.Hill DG.Lawrence AE. J. Med. Chem. 1977, 20: 718 -
3a
Ghera E.David YB.Rapoport H. J. Org. Chem. 1981, 46: 2059 -
3b
Uchida M.Morita S.Chihiro M.Kanbe T.Yamasaki K.Yabuuchi Y.Nakagawa K. Chem. Pharm. Bull. 1989, 37: 1517 -
3c
Yamada S.Goto T.Yamaguchi T.Aihara K.Kogi K.Narita S. Chem. Pharm. Bull. 1995, 43: 421 -
4a
Zymalkowski F.Kothari M. Arch. Pharm. (Weinheim. Ger.) 1970, 303: 667 -
4b
Beattie DE.Crossley R.Curran ACW.Dixon GT.Hill DG.Lawrence AE.Shepherd RG. J. Med. Chem. 1977, 20: 714 -
4c
Dammertz W.Reimann E. Arch. Pharm. (Weinheim, Ger.) 1980, 313: 826 -
4d
Calhoun W.Carlson RP.Crossley R.Datko LJ.Dietrich S.Heatherington K.Marshall LA.Meade PJ.Opalko A.Shepherd RG. J. Med. Chem. 1995, 38: 1473 - From cyclohexanone oxime:
-
5a
Irie H.Katayama I.Mizuno Y.Koyama J.Suzuta Y. Heterocycles 1979, 12: 771 -
5b
Koyama J.Sugita T.Suzuta Y.Irie H. Chem. Pharm. Bull. 1983, 31: 2601 -
5c
Hosokawa T.Shimo N.Maeda K.Sonoda A.Murahashi S. Tetrahedron Lett. 1976, 383 -
5d
Tsutsui H.Narasaka K. Chem. Lett. 2001, 526 - By condensation:
-
6a
Prelog V.Szpilfogel S. Helv. Chim. Acta 1945, 28: 1684 -
6b
Thummel RP.Kohli DK. J. Org. Chem. 1977, 42: 2742 -
6c
Chelucci G.Gladiali S.Marchetti M. J. Heterocycl. Chem. 1988, 25: 1761 -
7a
Okatani T.Koyama J.Tagahara K. Heterocycles 1989, 29: 1809 -
7b
Ohta K.Iwaoka J.Kamijyo Y.Okada M.Nomura Y. Nippon Kagaku Kaishi 1989, 1593 ; Chem. Abstr. 1990, 112, 158018 -
8a
Okazaki H.Onishi K.Soeda M.Ikefuji Y.Tamura R.Mochida I. Bull. Chem. Soc. Jpn. 1990, 63: 3167 -
8b
Fish RH.Thormodsen AD.Cremer GA. J. Am. Chem. Soc. 1982, 104: 5234 -
8c
Vierhapper FW.Eliel EL. J. Org. Chem. 1975, 40: 2729 -
9a
Curran ACW.Shepherd RG. J. Chem. Soc., Perkin Trans. 1 1976, 983 -
9b
Yamada S.Goto T.Shimanuki E.Narita S. Chem. Pharm. Bull. 1994, 42: 718 - 10
Sucheck SJ.Greenberg WA.Tolbert TJ.Wong C.-H. Angew. Chem., Int. Ed. 2000, 39: 1080 -
11a
Uenishi J.Hiraoka T.Hata S.Nishiwaki K.Yonemitsu O.Nakamura K.Tsukube H. J. Org. Chem. 1998, 63: 2481 -
11b
Uenishi J.Nishiwaki K.Hata S.Nakamura K. Tetrahedron Lett. 1994, 35: 7973 - 12 The racemic 1 was prepared by the reduction of 5,6,7,8-tetrahydroquinolin-8-one with NaBH4 quantitatively. For the synthesis of 5,6,7,8-tetrahydroquinolin-8-one, see:
Thummel RP.Lefoulon F.Cantu D.Mahadevan R. J. Org. Chem. 1984, 49: 2208 -
15a
Rotticci D.Haeffner F.Orenium C.Norin T.Hult K. J. Mol. Catal. B: Enzym. 1998, 5: 267 -
15b
Kazlauskas RJ.Weissfloch ANE.Rappaport AT.Cuccia LA. J. Org. Chem. 1991, 56: 2656 -
16a
Uenishi J.Hamada M.Takagi T.Yonemitsu O. Heterocycles 2001, 54: 735 -
16b
Uenishi J.Hiraoka T.Yuyama K.Yonemitsu O. Heterocycles 2000, 52: 719 -
16c
Uenishi J.Takagi T.Ueno T.Hiraoka T.Yonemitsu O.Tsukube H. Synlett 1999, 41 - 17 Racemic 2 has been reported, see:
Zymalkowski F.Rimek H. Arch. Pharm. (Weinheim, Ger.) 1961, 294: 759 - 18 Racemic 1 has been reported, see:
Fontenas C.Bejan E.Aït Haddou H.Balavoine GGA. Synth. Commun. 1995, 25: 629 - 19 Racemic 4 has been reported, see:
Jacobs C.Frotcher M.Dannhardt G.Hartmann RW. J. Med. Chem. 2000, 43: 1841
References
The details including the columns and conditions are described in the experimental section.
14(R)-Alcohol was specifically acetylated under the conditions, and no exception has ever been observed so far at least using Candida antarctica lipase.