Raney Nickel-Induced 3-Alkylation of Oxindole with Alcohols and Diols

Balázs Volk; Tibor Mezei; Gyula Simig

doi:10.1055/s-2002-23544

SHORTPAPER

Raney Nickel-Induced 3-Alkylation of Oxindole with Alcohols and Diols

Balázs Volk, Tibor Mezei, Gyula Simig*
Chemical Research Division, EGIS Pharmaceuticals Ltd., P.O. Box 100, 1475 Budapest, Hungary
Fax: +36(1)2655613; e-Mail: chemistry.rd@egis.hu;

Abstract

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Abstract

New reaction conditions are described, which turn Wenkert’s synthesis of 3-alkyloxindoles (Raney nickel-induced alkylation of oxindole with alcohols) into a reproducible and highly efficient synthetic tool. The method is also extended to the preparation of 3-(ω-hydroxyalkyl)oxindoles.

Key words

alcohols - alkylations - diols - oxindole - Raney nickel

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References

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