Raney Nickel-Induced 3-Alkylation of Oxindole with Alcohols and Diols

Abstract

New reaction conditions are described, which turn Wenkert’s synthesis of 3-alkyloxindoles (Raney nickel-induced alkylation of oxindole with alcohols) into a reproducible and highly efficient synthetic tool. The method is also extended to the preparation of 3-(ω-hydroxyalkyl)oxindoles.

alcohols - alkylations - diols - oxindole - Raney nickel

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