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Semin Respir Crit Care Med 2002; 23(2): 093-102
DOI: 10.1055/s-2002-25299
DOI: 10.1055/s-2002-25299
Pulmonary Langerhans' Cell Histiocytosis
Further Information
Publication History
Publication Date:
24 April 2002 (online)
ABSTRACT
Pulmonary Langerhans' cell histiocytosis (PLCH) remains an important diagnostic consideration in the differential diagnosis of diffuse infiltrative lung disease, particular among smokers. This review highlights recent progress in our understanding of the etiology, clinical presentation, and diagnostic and therapeutic approaches to this unusual lung disorder. Evolving studies strongly link the basic pathogenesis of PLCH as an uncommon reaction to tobacco smoke. Recent progress in the clinical approach to these patients has emphasized important roles for high-resolution computed tomographic (CT) scanning and immune reactive tissue markers including cluster differentiation (CD) 1a antigen in the diagnosis of this disorder. A rationale diagnostic algorithm and current management strategies are summarized.
KEYWORD
Pulmonary Langerhans' cell histiocytosis - pulmonary eosinophilic granuloma - Langerhans' cells
REFERENCES
- 1 Nezelof C, Basset F. Langerhans' cell histiocytosis research: past, present, and future. Hematol Oncol Clin North Am . 1998; 12 385-406
- 2 Howarth D M, Gilchrist G S, Mullan B P, Wiseman G A, Edmonson J H, Schomberg P J. Langerhans'cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer . 1999; 85 2278-2290
- 3 Colby T V, Lombard C. Histiocytosis X in the lung. Hum Pathol . 1983; 14 847-856
- 4 Lewis J. Eosinophilic granuloma and its variants with special reference to lung involvement. Q J Med . 1964; 33 337-359
- 5 Friedman P J, Liebow A A, Sokoloff J. Eosinophilic granuloma of lung: clinical aspects of primary histiocytosis in the adult. Medicine (Baltimore) . 1981; 60 385-396
- 6 Basset F, Corrin B, Spencer H. Pulmonary histiocytosis X. Am Rev Respir Dis . 1978; 118 811-820
- 7 Schonfeld N, Frank W, Wenig S. Clinical and radiologic features, lung function and therapeutic results in pulmonary histiocytosis X. Respiration . 1993; 60 38-44
- 8 Gaensler E A, Carrington C B. Open biopsy for chronic diffuse infiltrative lung disease: clinical, roentgenographic, and physiological correlations in 502 patients. Ann Thorac Surg . 1980; 30 411-426
- 9 Hirsch M S, Hong C K. Familial pulmonary histiocytosis-X. Am Rev Respir Dis . 1973; 107 831-835
- 10 Arico M, Nichols K, Whitlock J A. Familial clustering of Langerhans' cell histiocytosis. Br J Haematol . 1999; 107 883-888
- 11 Bernstrand C, Cederlund K, Ashtrom L, Henter J I. Smoking preceded pulmonary involvement in adults with Langerhans' cell histiocytosis diagnosed in childhood. Acta Paediatr . 2000; 89 1389-1392
- 12 Casolaro M A, Bernaudin J F, Saltini C, Ferrans V J, Crystal R G. Accumulation of Langerhans' cells on the epithelial surface of the lower respiratory tract in normal subjects in association with cigarette smoking. Am Rev Respir Dis . 1988; 137 406-411
- 13 Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans' cells. Nature . 1992; 360 258-261
- 14 Birbeck M S, Breathnach A S, Everall J D. An electron microscope study of basal melanocytes and high-level clear cells (Langerhans' cells) in vitiligo. J Invest Dermatol . 1961; 37 51-63
- 15 Tazi A, Bonay M, Grandsaigne M, Battesti J P, Hance A J, Soler P. Surface phenotype of Langerhans' cells and lymphocytes in granulomatous lesions from patients with pulmonary histiocytosis X. Am Rev Respir Dis . 1993; 147 1531-1536
- 16 Del Rio M, Hernanz A, de la Fuente M. Bombesin, gastrin-releasing peptide, and neuromedin C modulate murine lymphocyte proliferation through adherent accessory cells and activate protein kinase C. Peptides . 1994; 15 15-22
- 17 Lemaire I. Bombesin-related peptides modulate interleukin-1 production by alveolar macrophages. Neuropeptides . 1991; 20 217-223
- 18 Vassallo R, Ryu J H, Colby T V, Hartman T, Limper A H. Pulmonary Langerhans'-cell histiocytosis. N Engl J Med . 2000; 342 1969-1978
- 19 Asakura S, Colby T V, Limper A H. Tissue localization of transforming growth factor-beta1 in pulmonary eosinophilic granuloma. Am J Respir Crit Care Med . 1996; 154 1525-1530
- 20 Tazi A, Bonay M, Bergeron A, Grandsaigne M, Hance A J, Soler P. Role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the pathogenesis of adult pulmonary histiocytosis X. Thorax . 1996; 51 611-614
- 21 Zhang K, Gharaee-Kermani M, McGarry B, Remick D, Phan S H. TNF-alpha-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis. J Immunol . 1997; 158 954-959
- 22 Xing Z, Tremblay G M, Sime P J, Gauldie J. Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation. Am J Pathol . 1997; 150 59-66
- 23 King Jr E T, Schwarz M I, Dreisin R E, Pratt D S, Theofilopoulos A N. Circulating immune complexes in pulmonary eosinophilic granuloma. Ann Intern Med . 1979; 91 397-399
- 24 Willman C L, Busque L, Griffith B B. Langerhans'-cell histiocytosis (histiocytosis X): a clonal proliferative disease [see comments]. N Engl J Med . 1994; 331 154-160
- 25 Travis W D, Borok Z, Roum J H. Pulmonary Langerhans' cell granulomatosis (histiocytosis X): a clinicopathologic study of 48 cases. Am J Surg Pathol . 1993; 17 971-986
- 26 Housini I, Tomashefski Jr F J, Cohen A, Crass J, Kleinerman J. Transbronchial biopsy in patients with pulmonary eosinophilic granuloma: comparison with findings on open lung biopsy. Arch Pathol Lab Med . 1994; 118 523-530
- 27 Flint A, Lloyd R V, Colby T V, Wilson B W. Pulmonary histiocytosis X: immunoperoxidase staining for HLA-DR antigen and S100 protein. Arch Pathol Lab Med . 1986; 110 930-933
- 28 Webber D, Tron V, Askin F, Churg A. S-100 staining in the diagnosis of eosinophilic granuloma of lung. Am J Clin Pathol . 1985; 84 447-453
- 29 Colasante A, Poletti V, Rosini S, Ferracini R, Musiani P. Langerhans' cells in Langerhans' cell histiocytosis and peripheral adenocarcinomas of the lung. Am Rev Respir Dis . 1993; 148 752-759
- 30 Pomeranz S J, Proto A V. Histiocytosis X: unusual-confusing features of eosinophilic granuloma. Chest . 1986; 89 88-92
- 31 Crausman R S, Jennings C A, Tuder R M, Ackerson L M, Irvin C G, King Jr E T. Pulmonary histiocytosis X: pulmonary function and exercise pathophysiology. Am J Respir Crit Care Med . 1996; 153 426-435
- 32 Lacronique J, Roth C, Battesti J P, Basset F, Chretien J. Chest radiological features of pulmonary histiocytosis X: a report based on 50 adult cases. Thorax . 1982; 37 104-109
- 33 Moore A D, Godwin J D, Muller N L. Pulmonary histiocytosis X: comparison of radiographic and CT findings. Radiology . 1989; 172 249-254
- 34 Bonelli F S, Hartman T E, Swensen S J, Sherrick A. Accuracy of high-resolution CT in diagnosing lung diseases. Am J Roentgenol . 1998; 170 1507-1512
- 35 Brauner M W, Grenier P, Mouelhi M M, Mompoint D, Lenoir S. Pulmonary histiocytosis X: evaluation with high-resolution CT. Radiology . 1989; 172 255-258
- 36 Brauner M W, Grenier P, Tijani K, Battesti J P, Valeyre D. Pulmonary Langerhans' cell histiocytosis: evolution of lesions on CT scans [see comments]. Radiology . 1997; 204 497-502
- 37 Auerswald U, Barth J, Magnussen H. Value of CD-1-positive cells in bronchoalveolar lavage fluid for the diagnosis of pulmonary histiocytosis X. Lung . 1991; 169 305-309
- 38 Chollet S, Soler P, Dournovo P, Richard M S, Ferrans V J, Basset F. Diagnosis of pulmonary histiocytosis X by immunodetection of Langerhans' cells in bronchoalveolar lavage fluid. Am J Pathol . 1984; 115 225-232
- 39 Mogulkoc N, Veral A, Bishop P W, Bayindir U, Pickering C A, Egan J J. Pulmonary Langerhans' cell histiocytosis: radiologic resolution following smoking cessation. Chest . 1999; 115 1452-1455
- 40 Morimoto T, Matsumura T, Kitaichi M. [Rapid remission of pulmonary eosinophilic granuloma in a young male patient after cessation of smoking]. Nihon Kokyuki Gakkai Zasshi . 1999; 37 140-145
- 41 Von Essen S, West W, Sitorius M, Rennard S I. Complete resolution of roentgenographic changes in a patient with pulmonary histiocytosis X. Chest . 1990; 98 765-767
- 42 Benyounes B, Crestani B, Couvelard A, Vissuzaine C, Aubier M. Steroid-responsive pulmonary hypertension in a patient with Langerhans' cell granulomatosis (histiocytosis X). Chest . 1996; 110 284-286
- 43 Giona F, Caruso R, Testi A M. Langerhans' cell histiocytosis in adults: a clinical and therapeutic analysis of 11 patients from a single institution. Cancer . 1997; 80 1786-1791
- 44 Saven A, Burian C. Cladribine activity in adult langerhans'-cell histiocytosis. Blood . 1999; 93 4125-4130
- 45 Yeatman M, McNeil K, Smith J A. Lung transplantation in patients with systemic diseases: an eleven-year experience at Papworth Hospital. J Heart Lung Transplant . 1996; 15 144-149
- 46 Egan T M, Detterbeck F C, Keagy B A, Turpin S, Mill M R, Wilcox B R. Single lung transplantation for eosinophilic granulomatosis. South Med J . 1992; 85 551-553
- 47 Etienne B, Bertocchi M, Gamondes J P. Relapsing pulmonary Langerhans' cell histiocytosis after lung transplantation. Am J Respir Crit Care Med . 1998; 157 288-291
- 48 Habib S B, Congleton J, Carr D. Recurrence of recipient Langerhans' cell histiocytosis following bilateral lung transplantation [see comments]. Thorax . 1998; 53 323-325
- 49 Delobbe A, Durieu J, Duhamel A, Wallaert B. Determinants of survival in pulmonary Langerhans' cell granulomatosis (histiocytosis X). Groupe d'Etude en Pathologie Interstitielle de la Societe de Pathologie Thoracique du Nord. Eur Respir J . 1996; 9 2002-2006
- 50 Fartoukh M, Humbert M, Capron F. Severe pulmonary hypertension in histiocytosis X. Am J Respir Crit Care Med . 2000; 161 216-223
- 51 Crausman R S, King Jr E T. Pulmonary vascular involvement in pulmonary histiocytosis X. Chest . 1997; 112 1714
- 52 Harari S, Brenot F, Barberis M, Simmoneau G. Advanced pulmonary histiocytosis X is associated with severe pulmonary hypertension. Chest . 1997; 111 1142-1144
- 53 Lombard C M, Medeiros L J, Colby T V. Pulmonary histiocytosis X and carcinoma. Arch Pathol Lab Med . 1987; 111 339-341
- 54 Tomashefski J F, Khiyami A, Kleinerman J. Neoplasms associated with pulmonary eosinophilic granuloma. Arch Pathol Lab Med . 1991; 115 499-506
- 55 Burns B F, Colby T V, Dorfman R F. Langerhans' cell granulomatosis (histiocytosis X) associated with malignant lymphomas. Am J Surg Pathol . 1983; 7 529-531
- 56 Neumann M P, Frizzera G. The coexistence of Langerhans' cell granulomatosis and malignant lymphoma may take different forms: report of seven cases with a review of the literature. Hum Pathol . 1986; 17 1060-1065