Synlett 2002(5): 0707-0710
DOI: 10.1055/s-2002-25352
LETTER
© Georg Thieme Verlag Stuttgart · New York

Juliá-Colonna Asymmetric Epoxidation in a Continuously Operated Chemzyme Membrane Reactor

Svetlana B. Tsogoeva*a,c, Jens Wöltingera, Carsten Jostb, Dietmar Reicherta, Adolf Kühnleb, Hans-Peter Krimmera, Karlheinz Drauza
a Degussa AG, Research, Development and Applied Technology, Business Unit Fine Chemicals, P.O. Box 1345, 63403 Hanau-Wolfgang, Germany
b Creavis GmbH, Paul-Baumann-Straße 1, 45764 Marl, Germany
c Institut für Organische Chemie, Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany
Fax: +49(551)399660; e-Mail: stsogoe@gwdg.de;
Further Information

Publication History

Received 4 February 2002
Publication Date:
07 February 2007 (online)

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Abstract

Two novel soluble polymer-bound oligo-l-leucines 2 and 5, which can be retained by a membrane reactor system, have been prepared and used as catalysts for the continuously operated asymmetric epoxidation of chalcone. The optimized batch reaction conditions yield epoxychalcone in high enantioselectivities (up to 94%) and conversions (over 99%) after 15 minutes.