Abstract
Two synthetic strategies towards atropisomeric 2′,2′-disubstituted 1,8-bis(4′,4′-dipyridyl)naphthalenes using Stille cross-coupling of trimethylstannylpyridine derivatives and 1,8-diiodonaphthalene have been investigated. Introduction of substituents into the pyridyl moieties prior to the cross-coupling step provides higher overall yields than derivatization of 1,8-bis(4′,4′-dipyridyl)naphthalene under Ziegler reaction conditions.
Key words
Stille coupling - 1,8-dipyridylnaphthalenes - 2,4-disubstituted pyridines - Ziegler reaction - atropisomers
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