Planta Med 2002; 68(4): 349-354
DOI: 10.1055/s-2002-26738
Original Paper
Analysis
© Georg Thieme Verlag Stuttgart · New York

Complete LC/MS Analysis of a Tinnevelli Senna Pod Extract and Subsequent Isolation and Identification of Two New Benzophenone Glucosides

Christian Terreaux1 , Qi Wang1 , Jean-Robert Ioset1 , Karine Ndjoko1 , Wolf Grimminger2 , Kurt Hostettmann1
  • 1Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, Lausanne, Switzerland
  • 2Madaus AG, Köln, Germany
Weitere Informationen

Publikationsverlauf

May 18, 2001

August 5, 2001

Publikationsdatum:
02. Mai 2002 (online)

Abstract

The hydroalcoholic extract of Tinnevelli senna is widely used as a laxative phytomedicine. In order to improve the knowledge of the chemical composition of this extract, LC/MS and LC/MSn studies were performed, allowing the on-line identification of most of the known constituents, i. e., flavonoids, anthraquinones and the typical dianthronic sennosides. However, the identity of four compounds could not be ascertained on-line under the given LC/MS conditions. These substances were isolated and their structures elucidated as kaempferol, the naphthalene derivative tinnevellin 8-glucoside and two new carboxylated benzophenone glucosides.

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Prof. Kurt Hostettmann

Institut de Pharmacognosie et Phytochimie

BEP

Université de Lausanne

CH-1015 Lausanne

Telefon: +41 21 6924561

Fax: +41 21 6924565

eMail: kurt.hostettmann@ipp.unil.ch