Abstract
The hydroalcoholic extract of Tinnevelli senna is widely used as a laxative phytomedicine. In order to improve the knowledge of the chemical composition of this extract, LC/MS and LC/MSn studies were performed, allowing the on-line identification of most of the known constituents, i. e., flavonoids, anthraquinones and the typical dianthronic sennosides. However, the identity of four compounds could not be ascertained on-line under the given LC/MS conditions. These substances were isolated and their structures elucidated as kaempferol, the naphthalene derivative tinnevellin 8-glucoside and two new carboxylated benzophenone glucosides.
Key words
Cassia angustifolia
- Leguminosae - LC/MS - tinnevellin 8-glucoside - benzophenone glucosides - cassiaphenone A-2-glucoside - cassiaphenone B-2-glucoside
References
-
1
Soffer E E.
Constipation: an approach to diagnosis, treatment, referral.
Cleveland Clinic Journal of Medicine.
1999;
66
41-6
-
2
Sweeney M.
Constipation. Diagnosis and treatment.
Home Care Provider.
1997;
2
250-5
-
3
Pietrusko R G.
Use and abuse of laxatives.
American Journal of Hospital Pharmacy.
1977;
34
291-300
-
4
Falch B.
Senna im Vergleich zu andreren Laxantien.
Schweizer Apothekerzeitung.
1999;
24
815-8
-
5
Grimminger W, Wittholn K.
Analytics of senna drugs with regard to the toxicological discussion of anthranoids.
Pharmacology.
1993;
43
98-109
-
6
Lemli J, Toppet S, Cuveele J, Janssen G.
Naphthalene glycoside in Cassia senna and Cassia angustifolia
.
Planta Medica.
1981;
43
11-7
-
7 Markham K R. Techniques of flavonoid identification. London; Academic Press 1982
-
8
Zahir A, Jossang A, Bodo B, Hadi H A, Schaller H, Sevenet T.
Knerachelins A and B, antibacterial phenylacylphenols from Knema furfuracea
.
Journal of Natural Products.
1993;
56
1634-7
-
9
Arunachalam T, Anchel M, Nair M SR.
Synthesis of a hydroxyxanthone dicarboxylic acid, cassiaxanthone. Reactions of γ-resorcylic acid with phenols.
Journal of Organic Chemistry.
1972;
37
1262-6
-
10
Bennett G J, Lee H -H.
Xanthones from Guttiferae.
Phytochemistry.
1989;
28
967-98
Prof. Kurt Hostettmann
Institut de Pharmacognosie et Phytochimie
BEP
Université de Lausanne
CH-1015 Lausanne
Phone: +41 21 6924561
Fax: +41 21 6924565
Email: kurt.hostettmann@ipp.unil.ch
