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Planta Med 2002; 68(4): 326-329
DOI: 10.1055/s-2002-26741
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

The Effects of Higenamine on LPS-Induced
Experimental Disseminated Intravascular Coagulation (DIC) in Rats

Hye Sook Yun-Choi1 , Mi Kyung Pyo1 , Ki Churl Chang2 , Duck Hyung Lee3
  • 1Natural Products Research Institute, Seoul National University, Seoul, Korea
  • 2Department of Pharmacology, Cardiovascular Research Institute, College of Medicine, Gyeongsang National University, Chinju, Korea
  • 3Department of Chemistry, Sogang University, Seoul, Korea
Further Information

Publication History

June 27, 2001

August 25, 2001

Publication Date:
02 May 2002 (online)

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Abstract

The effect of higenamine, a benzyl-tetrahydroisoquinoline alkaloid of the roots of Aconitum spp. (Ranunculaceae), on disseminated intravascular coagulation (DIC), was investigated using an experimental DIC rat model. The oral administration of higenamine (10 mg/kg or 50 mg/kg), significantly ameliorated the decrease of fibrinogen level in plasma, the increase of fibrinogen/fibrin degradation product (FDP) level, and the prolongation of prothrombin time (PT) induced by the i. v. infusion of lipopolysaccharide (LPS). The prolongation of activated partial thrombin time (aPTT) and the decrease of platelet count were suppressed. The increase in serum aspartate aminotransferase (AST) and blood urea nitrogen (BUN) were also significantly prevented with higenamine. The above results are suggestive that higenamine has therapeutic potential for DIC and/or accompanying multiple organ failure (MOF).

Key words

Higenamine - benzyl-tetrahydroisoquinoline - Aconitum spp. - Ranunculaceae - disseminated intravascular coagulation (DIC) - multiple organ failure (MOF)

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Hye Sook Yun-Choi

Natural Products Research Institute

Seoul National University

Seoul 110-460, Korea

Phone: +82-2-740-8901

Fax: +82-2-742-9951

Email: hsyun@snu.ac.kr