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Planta Med 2002; 68(4): 377-379
DOI: 10.1055/s-2002-26748
Letter
© Georg Thieme Verlag Stuttgart · New York

Constituents of Burasaïa madagascarensis: A New Clerodane-Type Diterpene

Lengo Mambu1 , Voahangy Ramanandraibe2 , Marie Thérèse Martin3 , Alain Blond1 , Philippe Grellier4 , François Frappier1
  • 1Laboratoire de Chimie des Substances Naturelles, ESA 8041 CNRS , Muséum National d’Histoire Naturelle, Paris, France
  • 2Faculté des Sciences, Université d’Antananarivo, Madagascar
  • 3Institut de Chimie des Substances Naturelles (ICSN-CNRS), Gif-sur-Yvette, France
  • 4Laboratoire de Biologie Parasitaire, Muséum National d’Histoire Naturelle, Paris, France
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Publication History

June 22, 2001

September 30, 2001

Publication Date:
02 May 2002 (online)

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Abstract

From an ethanol extract of the stems of Burasaïa madagascarensis Thouars (Menispermaceae) were isolated N-acetylnornuciferine and two clerodane-type diterpenes, one of them, epicordatine, being new. The structures were established by the interpretation of the spectral data. All the described compounds exhibited weak antimalarial activity.

References

  • 1 Rasoanaivo P, Ratsimamanga-Urverg S, Rakoto-Ratsimamanga A, Raharisololalao A. Constituants chimiques de trois espèces de Burasaïa (Ménispermacées) endémiques de Madagascar.  Biochemical Systematics and Ecology. 1991;  19 433-7
    CrossrefPubMedGoogle Scholar
  • 2 Resplandy A. Sur les alcaloïdes du Burasaïa madagascariensis. Comptes Rendus Académie des Sciences (Paris), 1958; 247 : 2428 - 31; Thèse de Doctorat ès Sciences. Université de Paris Paris; 1958
    Google Scholar
  • 3 Hufford C D. Four new N-acetylnoraporphine alkaloids from Liriodendron tulipifera .  Phytochemistry. 1976;  15 1169-71
    CrossrefPubMedGoogle Scholar
  • 4 Martin M T, Frappier F, Rasoanaivo P, Randrianarivelojosia M. Spectral assignment of strychnobrasiline.  Magnetic Resonance Chemistry. 1996;  34 489-91
    PubMedGoogle Scholar
  • 5 Achenbach H, Hemrich  H. Clerodane-type diterpenes and other constituents of Penianthus zenkeri .  Phytochemistry. 1991;  30 1957-62
    CrossrefPubMedGoogle Scholar
  • 6 Dadoun H, Muller A H, Cesario M, Guilhem J, Pascard C. Cordatin, a new diterpene from Apasristhmium cordatum .  Phytochemistry. 1987;  26 2108-10
    CrossrefPubMedGoogle Scholar
  • 7 Overton K H, Weir N G, Wylie A. The stereochemistry of the Colombo root bitter principles. Journal of the Chemical Society 1966: 1482-90
    Google Scholar
  • 8 Tuntiwachwuttikul P, Boonrasri N, Bremner J B, Taylor W C. Rearranged clerodane diterpenes from Tinospora baenzigeri .  Phytochemistry. 1999;  52 1335-40
    CrossrefPubMedGoogle Scholar
  • 9 Wright C W, Phillipson J D. Natural products and the development of selective antiprotozoal drugs.  Phytotherapy Research. 1990;  4 127-39
    PubMedGoogle Scholar
  • 10 Frappier F, Jossang A, Soudon J, Calvo F, Rasoanaivo P, Ratsimamanga-Urverg S, Saez J, Schrével J, Grellier P. Bisbenzylisoquinoleines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cells.  Antimicrobial Agents Chemotherapy. 1996;  40 1476-81
    PubMedGoogle Scholar

Dr. François Frappier

Laboratoire de Chimie des Substances Naturelles, ESA 8041 CNRS

Muséum National d"Histoire Naturelle

63 rue Buffon, 75231 Paris Cedex 05, France

Email: frappier@mnhn.fr.

Fax: +33-01-40-79-31-35