Planta Med 2002; 68(4): 375-376
DOI: 10.1055/s-2002-26757
Letter
© Georg Thieme Verlag Stuttgart · New York

Shogaols from Zingiber officinale Protect IMR32 Human Neuroblastoma and Normal Human Umbilical Vein Endothelial Cells from β-Amyloid(25 - 35) Insult

Darrick S. H. L. Kim1 , Dong-Seon Kim1 , Marissa N. Oppel1
  • 1Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, USA
Further Information

Publication History

April 11, 2001

October 21, 2001

Publication Date:
02 May 2002 (online)

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Abstract

From the rhizome of Zingiber officinale L. (Zingiberaceae), four shogaols that protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from β-amyloid(25 - 35) insult at EC50 = 4.5 - 81 μM were isolated. The efficacy of cell protection from β-amyloid(25 - 35) insult by these shogaols was shown to improve as the length of the side chain increases.

References

Darrick S. H. L. Kim

Curxcel Corp. The Business and Technology Center

1291 Cumberland Ave.

West Lafayette, IN 47906

USA

Phone: +1 (847) 343-2330

Email: dkim@curxcel.com